(Q28594958)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1 (English)

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

GOA release 2020-03-11

Cut-like homeobox 1

1 reference

polycystic kidney disease

GOA release 2020-03-11

acceleration

0 references

1 reference

inferred from title

author

Gregory Vanden Heuvel

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

Madhulika Sharma

2

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Dianne Vassmer

3

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Brandon Chapman

4

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Binu Paul

5

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Jing Zhou

6

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Neal I Alcalay

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Jennifer G Brantley

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Darren P Wallace

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Robin L Maser

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

publication date

1 October 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

American Journal of Physiology - Renal Physiology

15 January 2020

published in

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

volume

295

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

issue

6

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

page(s)

F1725-34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor

15 January 2020

cites work

1 reference

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The ion channel polycystin-2 is required for left-right axis determination in mice

17 March 2017

1 reference

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PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

17 March 2017

1 reference

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The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

17 March 2017

1 reference

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Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease

17 March 2017

1 reference

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Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene

17 March 2017

1 reference

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S phase-specific proteolytic cleavage is required to activate stable DNA binding by the CDP/Cut homeodomain protein

17 March 2017

1 reference

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Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation, cell growth and development

17 March 2017

1 reference

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The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase

17 March 2017

1 reference

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CASP, a novel, highly conserved alternative-splicing product of the CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and interacts with full-length CDP in vitro

17 March 2017

1 reference

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Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation

17 March 2017

1 reference

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PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

17 March 2017

1 reference

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Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer

17 March 2017

1 reference

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Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604819

Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604819

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604819

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604819

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604819

Regulation of cell proliferation and differentiation in the kidney.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604819

The multiple roles of CUX1: insights from mouse models and cell-based assays

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604819

Differentiation-induced cleavage of Cutl1/CDP generates a novel dominant-negative isoform that regulates mammary gene expression

29 September 2017

1 reference

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Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604819

OFD1 is a centrosomal/basal body protein expressed during mesenchymal-epithelial transition in human nephrogenesis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604819

Polycystins and mechanosensation in renal and nodal cilia

29 September 2017

1 reference

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Murine models of polycystic kidney disease: molecular and therapeutic insights

29 September 2017

1 reference

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Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD.

29 September 2017

1 reference

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Genetics and pathogenesis of polycystic kidney disease.

29 September 2017

1 reference

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Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604819

PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats

29 September 2017

1 reference

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The genetics and physiology of polycystic kidney disease

29 September 2017

1 reference

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Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease

29 September 2017

1 reference

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

29 September 2017

1 reference

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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

29 September 2017

1 reference

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1992 Homer Smith Award. Fluid secretion, cellular proliferation, and the pathogenesis of renal epithelial cysts.

29 September 2017

1 reference

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A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation

29 September 2017

1 reference

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Characterization of a tissue-specific CDP/Cux isoform, p75, activated in breast tumor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604819

Functional defects in lysosomal enzymes in autosomal dominant polycystic kidney disease (ADPKD): abnormalities in synthesis, molecular processing, polarity, and secretion

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2604819

A unique variant of a homeobox gene related to Drosophila cut is expressed in mouse testis.

3 June 2018

1 reference

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TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice.

3 June 2018

1 reference

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Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation.

3 June 2018

1 reference

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3 June 2018

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Congenital murine polycystic kidney disease. II. Pathogenesis of tubular cyst formation

3 June 2018

1 reference

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Patterns of expression of cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos

3 June 2018

1 reference

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Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.

3 June 2018

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Polycystic kidneys caused by sustained expression of Cux1 isoform p75.

21 January 2018

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The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.

21 January 2018

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Kinesin Family Member 12 Is a Candidate Polycystic Kidney Disease Modifier in the cpk Mouse

21 January 2018

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In vitro modulation of cyst formation by a novel tyrosine kinase inhibitor.

21 January 2018

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Hair defects and pup loss in mice with targeted deletion of the first cut repeat domain of the Cux/CDP homeoprotein gene

21 January 2018

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Expression of a cut-related homeobox gene in developing and polycystic mouse kidney.

21 January 2018

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Prevalence of abnormal urinary albumin excretion rate in hypertensive patients with impaired fasting glucose and its association with cardiovascular disease

21 January 2018

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The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium

21 January 2018

1 reference

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Differential expression of Cux-1 and p21 in polycystic kidneys from Pkd1 null and cpk mice

27 November 2018

1 reference

12 December 2020

Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells

1 reference

12 December 2020

Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor

1 reference

12 December 2020

Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model

1 reference

12 December 2020

Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects

1 reference

12 December 2020

Polycystic kidney disease--the ciliary connection

1 reference

12 December 2020

Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist

1 reference

12 December 2020

Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Autosomal recessive polycystic kidney disease in a murine model. A gross and microscopic description

1 reference

12 December 2020

Hereditary error in epidermal growth factor prohormone metabolism in a rat model of autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Renal cysts in transgenic mice expressing transforming growth factor-alpha

1 reference

12 December 2020

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1 reference

12 December 2020

Analysis of the genomic sequence for the autosomal dominant polycystic kidney disease (PKD1) gene predicts the presence of a leucine-rich repeat. The American PKD1 Consortium (APKD1 Consortium)

1 reference

12 December 2020

Renal expression of a transforming growth factor-alpha transgene accelerates the progression of inherited, slowly progressive polycystic kidney disease in the mouse

1 reference

12 December 2020

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1 reference

12 December 2020

Alterations of cathepsins B, H and L in proximal tubules from polycystic kidneys of the Han:SPRD rat

1 reference

12 December 2020

Expression of the cyclin kinase inhibitor, p27kip1, in developing and mature human kidney

1 reference

12 December 2020

Somatic inactivation of Pkd2 results in polycystic kidney disease

1 reference

12 December 2020

Functional activity of epidermal growth factor receptors in autosomal recessive polycystic kidney disease

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12 December 2020

10.1152/AJPRENAL.90420.2008

Identifiers

DOI

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829740%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

2 references

1 February 2017