(Q21494567)

SOCS box-like domain superfamily

1 reference

SH2 domain superfamily

1 reference

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SOCS box domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SOCS3, SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein kinase inhibitor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35718&geneProductId=UniProtKB:O35718

1 reference

24 April 2018

protein binding

3 references

14 February 2019

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

14 February 2019

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

14 February 2019

Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

phosphotyrosine residue binding

1 reference

14 February 2019

Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

1-phosphatidylinositol-3-kinase regulator activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

1 reference

14 February 2019

TAS

cytoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

phosphatidylinositol 3-kinase complex

ISO

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

regulation of protein phosphorylation

biological process

1 reference

14 February 2019

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

trophoblast giant cell differentiation

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

14 February 2019

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

negative regulation of protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35718&geneProductId=UniProtKB:O35718

1 reference

24 April 2018

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35718&geneProductId=UniProtKB:O35718

1 reference

24 April 2018

spongiotrophoblast differentiation

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

14 February 2019

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

placenta blood vessel development

1 reference

14 February 2019

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

negative regulation of apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

1 reference

14 February 2019

negative regulation of insulin receptor signaling pathway

1 reference

24 April 2018

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35718&geneProductId=UniProtKB:O35718

branching involved in labyrinthine layer morphogenesis

1 reference

14 February 2019

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

protein ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

1 reference

14 February 2019

positive regulation of cell differentiation

regulation of cell differentiation

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

14 February 2019

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

regulation of growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

1 reference

14 February 2019

negative regulation of inflammatory response

1 reference

14 February 2019

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

negative regulation of receptor signaling pathway via JAK-STAT

cellular response to leukemia inhibitory factor

ISO

IEP

1 reference

14 February 2019

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

IEP

signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

regulation of phosphatidylinositol 3-kinase activity

ISO

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

negative regulation of insulin receptor signaling pathway

phosphatidylinositol phosphate biosynthetic process

2 references

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35718

1 reference

SOCS box domain

1 reference

SOCS3, SH2 domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016