(Q21494797)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27601

G-protein alpha subunit, group 12/13

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27601

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27601

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

1 reference

8 April 2019

GTP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

1 reference

8 April 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

1 reference

8 April 2019

guanyl nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

1 reference

8 April 2019

GTPase activity

Galpha12 and Galpha13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

21 June 2018

Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

21 June 2018

G protein-coupled receptor binding

type 1 angiotensin receptor binding

ISO

D5 dopamine receptor binding

ISO

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

G protein-coupled receptor binding

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

10 September 2018

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

GTPase activity

Galpha12 and Galpha13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

cell component

melanosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

1 reference

8 April 2019

heterotrimeric G-protein complex

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

21 June 2018

Galpha12 and Galpha13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

21 June 2018

Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

ISA

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

1 reference

10 September 2018

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

1 reference

10 September 2018

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

1 reference

8 April 2019

brush border membrane

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

heterotrimeric G-protein complex

Galpha12 and Galpha13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

ISA

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

14 February 2019

RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

14 February 2019

RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

14 February 2019

RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

14 February 2019

RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

nucleus

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

cytoplasm

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

biological process

cell differentiation

1 reference

8 April 2019

Galpha12 and Galpha13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

intracellular signal transduction

1 reference

8 April 2019

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

regulation of cell migration

1 reference

8 April 2019

Interaction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

21 June 2018

Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

in utero embryonic development

1 reference

8 April 2019

Interaction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

angiogenesis

1 reference

8 April 2019

Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

regulation of cell shape

1 reference

8 April 2019

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

branching involved in blood vessel morphogenesis

1 reference

8 April 2019

Essential role for Galpha13 in endothelial cells during embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

platelet activation

1 reference

8 April 2019

G13 is an essential mediator of platelet activation in hemostasis and thrombosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

G protein-coupled receptor signaling pathway

Galpha12 and Galpha13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

ISO

8 April 2019

Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

activation of phospholipase D activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

21 June 2018

Regions on adenylyl cyclase VII required for selective regulation by the G13 pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27601&geneProductId=UniProtKB:P27601

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

Rho protein signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

3 references

8 April 2019

8 April 2019

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27601

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016