(Q21494938)

http://www.ebi.ac.uk/interpro/protein/P25446

Death-like domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25446

membrane proteins

1 reference

inferred from GOA cell component → membrane

Fas receptor, death domain, protein family

1 reference

Death domain, protein family

1 reference

Fas receptor, N-terminal domain, protein family

1 reference

TNFR/NGFR cysteine-rich region, protein family

1 reference

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

1 reference

12 September 2018

1 reference

12 September 2018

12 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Daxx, a novel Fas-binding protein that activates JNK and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Palmitoylation is required for efficient Fas cell death signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

transmembrane signaling receptor activity

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

tumor necrosis factor binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25446&geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

identical protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

protein-containing complex binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

tumor necrosis factor-activated receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

2 references

1 reference

8 April 2019

A naturally occurring soluble isoform of murine Fas generated by alternative splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

integral component of plasma membrane

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25446&geneProductId=UniProtKB:P25446

external side of plasma membrane

IBA

6 references

8 April 2019

Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25446&geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25446&geneProductId=UniProtKB:P25446

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

A naturally occurring soluble isoform of murine Fas generated by alternative splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

death-inducing signaling complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

apical plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

perinuclear region of cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

5 June 2018

Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25446&geneProductId=UniProtKB:P25446

activation-induced cell death of T cells

3 references

8 April 2019

Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Fas is not essential for lamina propria T lymphocyte homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

1 reference

14 February 2019

Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

positive regulation of extrinsic apoptotic signaling pathway

IEP

1 reference

14 February 2019

The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

negative thymic T cell selection

1 reference

8 April 2019

Several different cell surface molecules control negative selection of medullary thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

regulation of lymphocyte differentiation

1 reference

8 April 2019

Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

motor neuron apoptotic process

1 reference

8 April 2019

Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25446&geneProductId=UniProtKB:P25446

inflammatory response

1 reference

5 June 2018

regulation of myeloid cell differentiation

IBA

1 reference

8 April 2019

Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

protein homooligomerization

1 reference

8 April 2019

A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

B cell mediated immunity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy

neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

positive regulation of protein homooligomerization

1 reference

8 April 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

cellular response to lithium ion

1 reference

8 April 2019

NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

positive regulation of lymphocyte apoptotic process

1 reference

14 February 2019

The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

negative regulation of apoptotic process

1 reference

8 April 2019

A naturally occurring soluble isoform of murine Fas generated by alternative splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

positive regulation of release of cytochrome c from mitochondria

1 reference

8 April 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

negative regulation of B cell activation

1 reference

8 April 2019

Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

extrinsic apoptotic signaling pathway in absence of ligand

1 reference

8 April 2019

Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

hepatocyte apoptotic process

1 reference

8 April 2019

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

immunoglobulin production

IGI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

extrinsic apoptotic signaling pathway via death domain receptors

12 references

8 April 2019

Several different cell surface molecules control negative selection of medullary thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

response to lipopolysaccharide

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25446&geneProductId=UniProtKB:P25446

tumor necrosis factor-mediated signaling pathway

IBA

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

response to toxic substance

1 reference

8 April 2019

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

positive regulation of protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

regulation of stress-activated MAPK cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

cellular response to amino acid starvation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

Fas signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

positive regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

cellular response to hyperoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

extrinsic apoptotic signaling pathway

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

YAP1 increases organ size and expands undifferentiated progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

positive regulation of apoptotic signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

positive regulation of cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

dendrite regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

positive regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

apoptotic signaling pathway

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

8 April 2019

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

negative regulation of Schwann cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

negative regulation of Schwann cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446

lymphocyte apoptotic process

1 reference

8 April 2019

The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446