(Q21495013)

T-lymphoma invasion and metastasis-inducing protein 1

1 reference

PDZ superfamily

1 reference

PH-like domain superfamily

1 reference

pleckstrin homology domain, protein family

1 reference

PDZ domain, protein family

1 reference

Raf-like Ras-binding domain, protein family

1 reference

Dbl homology (DH) domain, protein family

1 reference

Guanine-nucleotide dissociation stimulator, CDC24, conserved site, protein family

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

guanyl-nucleotide exchange factor activity

English

molecular function

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

14 February 2019

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2

ephrin receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

2 references

cell-cell contact zone

2 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

14 February 2019

External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

14 February 2019

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

somatodendritic compartment

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

glutamatergic synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

extrinsic component of postsynaptic density membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

intracellular signal transduction

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

regulation of GTPase activity

IEA

1 reference

14 February 2019

TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

ephrin receptor signaling pathway

1 reference

14 February 2019

Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

small GTPase mediated signal transduction

1 reference

14 February 2019

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

regulation of non-canonical Wnt signaling pathway

1 reference

14 February 2019

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

brain-derived neurotrophic factor receptor signaling pathway

IGI

1 reference

14 February 2019

TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

regulation of dopaminergic neuron differentiation

1 reference

14 February 2019

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

positive regulation of protein binding

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

2 references

Rac protein signal transduction

ISS

regulation of Rho protein signal transduction

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

activation of GTPase activity

IEA

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

14 February 2019

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

positive regulation of cell population proliferation

IEA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

positive regulation of cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

regulation of epithelial to mesenchymal transition

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

cardiac muscle hypertrophy

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

positive regulation of JUN kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

positive regulation of dendritic spine morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

protein localization to membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

NMDA selective glutamate receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

positive regulation of Schwann cell chemotaxis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

regulation of modification of postsynaptic actin cytoskeleton

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

neuron projection extension

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60610

1 reference

Dbl homology (DH) domain

1 reference

pleckstrin homology domain

1 reference

Guanine-nucleotide dissociation stimulator, CDC24, conserved site

1 reference

PDZ domain

1 reference

Identifiers

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016