(Q28506616)

English

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting

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scholarly article

1 reference

PubMed publication ID

24 January 2017

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting (English)

1 reference

PubMed publication ID

24 January 2017

Serum response factor

1 reference

GOA release 2020-03-11

T-lymphoma invasion and metastasis-inducing protein 1

1 reference

GOA release 2020-03-11

Rac family small GTPase 1

1 reference

GOA release 2020-03-11

object named as

John Sondek

4

0 references

object named as

Mark A. Lemmon

5

0 references

author name string

Mark A. Baumeister

1

1 reference

PubMed publication ID

24 January 2017

Lenka Martinu

2

1 reference

PubMed publication ID

24 January 2017

Kent L. Rossman

3

1 reference

PubMed publication ID

24 January 2017

Margaret M. Chou

6

1 reference

PubMed publication ID

24 January 2017

language of work or name

0 references

publication date

28 March 2003

1 reference

PubMed publication ID

24 January 2017

Journal of Biological Chemistry

1 reference

PubMed publication ID

24 January 2017

278

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PubMed publication ID

24 January 2017

13

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PubMed publication ID

24 January 2017

11457–11464

1 reference

PubMed publication ID

24 January 2017

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Dbl family guanine nucleotide exchange factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

A role for Rac in Tiam1-induced membrane ruffling and invasion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Inhibition of invasion of epithelial cells by Tiam1-Rac signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Rho GTPases and their effector proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

The Dbl family of oncogenes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Membrane binding and enzymatic activation of a Dbl homology domain require the neighboring pleckstrin homology domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Distinct roles for DH and PH domains in the Lbc oncogene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Modulation of oncogenic DBL activity by phosphoinositol phosphate binding to pleckstrin homology domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

A PtdIns(3)P-specific probe cycles on and off host cell membranes during Salmonella invasion of mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

[48] Analysis of phosphoinositide binding by Pleckstrin homology domain from dynamin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Investigation of the GTP-binding/GTPase cycle of Cdc42Hs using fluorescence spectroscopy.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Translocation of the Rac1 guanine nucleotide exchange factor Tiam1 induced by platelet-derived growth factor and lysophosphatidic acid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Intracellular Regulation: Rac and Bcr regulate phagocytic phoxes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Regulation of proto-Dbl by intracellular membrane targeting and protein stability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Critical role of the pleckstrin homology and cysteine-rich domains in Vav signaling and transforming activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Targeting of Golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and -independent components.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211901200

21 January 2018

Identifiers

10.1074/JBC.M211901200

0 references

PubMed publication ID

1 reference

PubMed publication ID

24 January 2017

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