(Q21495077)

http://www.ebi.ac.uk/interpro/protein/O35280

Checkpoint kinase 1, catalytic domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

IEA

protein kinase activity

3 references

1 reference

14 February 2019

protein serine/threonine kinase activity

IEA

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35280&geneProductId=UniProtKB:O35280

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35280&geneProductId=UniProtKB:O35280

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35280&geneProductId=UniProtKB:O35280

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35280&geneProductId=UniProtKB:O35280

2 references

protein domain specific binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

protein serine/threonine kinase activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

1 reference

14 February 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

3 references

microtubule organizing center

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

1 reference

14 February 2019

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35280&geneProductId=UniProtKB:O35280

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35280&geneProductId=UniProtKB:O35280

24 April 2018

Large-scale identification of mammalian proteins localized to nuclear sub-compartments

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35280&geneProductId=UniProtKB:O35280

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

condensed nuclear chromosome

2 references

2 references

3 references

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

Large-scale identification of mammalian proteins localized to nuclear sub-compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

IEA

1 reference

14 February 2019

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

regulation of histone H3-K9 acetylation

1 reference

14 February 2019

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

cellular response to DNA damage stimulus

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

regulation of cell population proliferation

1 reference

14 February 2019

VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

G2/M transition of mitotic cell cycle

1 reference

14 February 2019

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

regulation of gene expression

1 reference

14 February 2019

VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

mitotic cell cycle checkpoint signaling

1 reference

14 February 2019

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

apoptotic process involved in development

1 reference

14 February 2019

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

1 reference

14 February 2019

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

inner cell mass cell proliferation

1 reference

14 February 2019

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

intracellular signal transduction

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

DNA damage checkpoint signaling

IBA

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

positive regulation of cell cycle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

protein phosphorylation

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35280&geneProductId=UniProtKB:O35280

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35280&geneProductId=UniProtKB:O35280

24 April 2018

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35280&geneProductId=UniProtKB:O35280

negative regulation of G2/M transition of mitotic cell cycle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

negative regulation of DNA biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

protein phosphorylation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35280