(Q21495079)

Ankyrin repeat-containing domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Ankyrin repeat-containing domain, protein family

1 reference

Integrin-linked protein kinase, pseudokinase domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Ankyrin repeat, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

protein serine/threonine kinase activity

3 references

21 June 2018

Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

8 references

14 February 2019

Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Integrin-linked kinase is an adaptor with essential functions during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

2 references

protein kinase activity

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

protein domain specific binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

protein serine/threonine kinase activity

4 references

14 February 2019

Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

3 references

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

6 references

21 June 2018

Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

3 references

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O55222&geneProductId=UniProtKB:O55222

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

3 references

7 references

14 February 2019

Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

1 reference

14 February 2019

Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

protein kinase B signaling

1 reference

14 February 2019

Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system

Schwann cell development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

outflow tract morphogenesis

1 reference

14 February 2019

Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

myelination in peripheral nervous system

1 reference

14 February 2019

Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

branching involved in ureteric bud morphogenesis

1 reference

14 February 2019

Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

positive regulation of osteoblast differentiation

IDA

1 reference

14 February 2019

CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

cell projection organization

1 reference

14 February 2019

Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

establishment or maintenance of epithelial cell apical/basal polarity

1 reference

14 February 2019

Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

positive regulation of BMP signaling pathway

1 reference

14 February 2019

CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

1 reference

14 February 2019

Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

integrin-mediated signaling pathway

IBA

3 references

14 February 2019

Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

substrate adhesion-dependent cell spreading

IBA

3 references

positive regulation of cell population proliferation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

peptidyl-serine phosphorylation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O55222

ankyrin repeat-containing domain

has part(s)

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

protein kinase domain

1 reference

ankyrin repeat

1 reference

Integrin-linked protein kinase, pseudokinase domain

1 reference