(Q21495135)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60680

I-kappa-kinase-beta NEMO binding domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

English

molecular function

scaffold protein binding

1 reference

14 February 2019

SASH1 is a scaffold molecule in endothelial TLR4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60680&geneProductId=UniProtKB:Q60680

1 reference

5 June 2018

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

14 February 2019

The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

protein binding

12 references

14 February 2019

Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

Inhibition of IkappaB kinase by vaccinia virus virulence factor B14

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

Signal processing by its coil zipper domain activates IKK gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

An anti-interferon activity shared by paramyxovirus C proteins: inhibition of Toll-like receptor 7/9-dependent alpha interferon induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

1 reference

14 February 2019

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

1 reference

14 February 2019

identical protein binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60680&geneProductId=UniProtKB:Q60680

IkappaB kinase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

cytoplasmic side of plasma membrane

cell component

1 reference

14 February 2019

HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

1 reference

14 February 2019

intracellular membrane-bounded organelle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

nucleoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

CD40 receptor complex

1 reference

14 February 2019

HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

cytosol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

biological process

I-kappaB phosphorylation

TAS

1 reference

14 February 2019

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

TAS

lactation

mammary gland epithelial cell proliferation

mammary gland alveolus development

response to muscle stretch

1 reference

14 February 2019

Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

morphogenesis of an epithelial sheet

1 reference

14 February 2019

A dual role for Ikk alpha in tooth development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

1 reference

14 February 2019

positive regulation of I-kappaB kinase/NF-kappaB signaling

odontogenesis of dentin-containing tooth

2 references

1 reference

14 February 2019

A dual role for Ikk alpha in tooth development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

signal transduction

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60680&geneProductId=UniProtKB:Q60680

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60680&geneProductId=UniProtKB:Q60680

1 reference

5 June 2018

peptidyl-serine phosphorylation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

tumor necrosis factor-mediated signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60680&geneProductId=UniProtKB:Q60680

1 reference

5 June 2018

positive regulation of transcription by RNA polymerase II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

positive regulation of NF-kappaB transcription factor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

I-kappaB kinase/NF-kappaB signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

cellular response to reactive oxygen species

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

NIK/NF-kappaB signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

positive regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

defense response to virus

1 reference

14 February 2019

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

cellular response to cadmium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

negative regulation of NF-kappaB transcription factor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

Rho protein signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

response to organic substance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

response to lipopolysaccharide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

striated muscle cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

response to cholecystokinin

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

positive regulation of I-kappaB kinase/NF-kappaB signaling

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

14 February 2019

IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680