(Q21495411)

http://www.ebi.ac.uk/interpro/protein/O35425

Bcl-2-related ovarian killer protein

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35425

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

signaling receptor binding

1 reference

14 February 2019

The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

ubiquitin protein ligase binding

1 reference

14 February 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

protein homodimerization activity

IPI

1 reference

24 April 2018

Intracellular localization of the BCL-2 family member BOK and functional implications

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35425&geneProductId=UniProtKB:O35425

protein heterodimerization activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

3 references

integral component of membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

3 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

nuclear outer membrane

1 reference

14 February 2019

mitochondrial inner membrane

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

endoplasmic reticulum

endoplasmic reticulum membrane

ISO

3 references

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

Intracellular localization of the BCL-2 family member BOK and functional implications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

3 references

2 references

mitochondrial membranes

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

14 February 2019

Intracellular localization of the BCL-2 family member BOK and functional implications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

trans-Golgi network membrane

1 reference

14 February 2019

Intracellular localization of the BCL-2 family member BOK and functional implications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

cis-Golgi network membrane

1 reference

14 February 2019

Intracellular localization of the BCL-2 family member BOK and functional implications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

regulation of apoptotic process

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL

neuron apoptotic process

1 reference

14 February 2019

GOA

curator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

male gonad development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

oligodendrocyte differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

3 references

activation of cysteine-type endopeptidase activity involved in apoptotic process

3 references

cellular component disassembly involved in execution phase of apoptosis

1 reference

14 February 2019

Intracellular localization of the BCL-2 family member BOK and functional implications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

1 reference

14 February 2019

BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

negative regulation of neuron apoptotic process

1 reference

14 February 2019

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

protein complex oligomerization

1 reference

14 February 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

negative regulation of mitochondrial depolarization

1 reference

14 February 2019

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

negative regulation of necroptotic process

1 reference

14 February 2019

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

positive regulation of execution phase of apoptosis

3 references

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

1 reference

14 February 2019

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

1 reference

14 February 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

regulation of chorionic trophoblast cell proliferation

3 references

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of PERK-mediated unfolded protein response

1 reference

14 February 2019

BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

regulation of granulosa cell apoptotic process

3 references

positive regulation of intrinsic apoptotic signaling pathway

1 reference

14 February 2019

Intracellular localization of the BCL-2 family member BOK and functional implications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425

extrinsic apoptotic signaling pathway in absence of ligand

IBA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35425