(Q21495674)

http://www.ebi.ac.uk/interpro/protein/P20491

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Phosphorylated immunoreceptor signalling ITAM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

16 July 2018

Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

10 references

14 February 2019

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Mincle is an ITAM-coupled activating receptor that senses damaged cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Activation of neutrophils by a novel triggering immunoglobulin-like receptor MAIR-IV

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

A role for the ITAM signaling module in specifying cytokine-receptor functions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

4 references

16 July 2018

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

16 July 2018

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

16 July 2018

Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

transmembrane signaling receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

protein homodimerization activity

IEA

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

IEA

IgE receptor activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

5 references

14 February 2019

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

integral component of membrane

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

2 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

Fc-epsilon receptor I complex

1 reference

16 July 2018

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

1 reference

14 February 2019

Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

external side of plasma membrane

TAS

integral component of plasma membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

3 references

external side of plasma membrane

3 references

14 February 2019

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

positive regulation of phagocytosis

biological process

3 references

16 July 2018

Targeting to Fcgamma receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

16 July 2018

Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

16 July 2018

FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

Fc receptor mediated stimulatory signaling pathway

1 reference

16 July 2018

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

antigen processing and presentation of exogenous peptide antigen via MHC class II

1 reference

16 July 2018

Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

positive regulation of interleukin-10 production

1 reference

14 February 2019

FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization

receptor internalization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

positive regulation of type IIa hypersensitivity

3 references

14 February 2019

FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

neutrophil activation involved in immune response

1 reference

16 July 2018

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

serotonin secretion by platelet

1 reference

14 February 2019

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

cellular response to low-density lipoprotein particle stimulus

1 reference

14 February 2019

Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice

neutrophil chemotaxis

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

16 July 2018

Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

16 July 2018

Cutting edge: Fc receptor type I for IgG on macrophages and complement mediate the inflammatory response in immune complex peritonitis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

antigen processing and presentation of exogenous peptide antigen via MHC class I

1 reference

16 July 2018

FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

cell surface receptor signaling pathway

4 references

14 February 2019

FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses

phagocytosis, engulfment

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Targeting to Fcgamma receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

positive regulation of immune response

1 reference

14 February 2019

IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

positive regulation of type I hypersensitivity

1 reference

14 February 2019

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

defense response to bacterium

1 reference

16 July 2018

Targeting to Fcgamma receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

immunoglobulin mediated immune response

2 references

16 July 2018

Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

16 July 2018

IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

Fc-gamma receptor signaling pathway

1 reference

16 July 2018

C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

regulation of immune response

1 reference

14 February 2019

FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

positive regulation of tumor necrosis factor production

3 references

14 February 2019

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Cutting edge: Fc receptor type I for IgG on macrophages and complement mediate the inflammatory response in immune complex peritonitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

integrin-mediated signaling pathway

1 reference

14 February 2019

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

regulation of platelet activation

1 reference

16 July 2018

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor

innate immune response

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

protein localization to plasma membrane

1 reference

14 February 2019

Activation of neutrophils by a novel triggering immunoglobulin-like receptor MAIR-IV

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

positive regulation of type III hypersensitivity

1 reference

14 February 2019

Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

T cell differentiation involved in immune response

1 reference

16 July 2018

C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20491&geneProductId=UniProtKB:P20491

1 reference

14 February 2019

Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

osteoclast differentiation

1 reference

14 February 2019

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR).

interleukin-2 production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

positive regulation of interleukin-4 production

IPI

1 reference

14 February 2019

Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

interleukin-3-mediated signaling pathway

1 reference

14 February 2019

Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

immune system process

1 reference

14 February 2019

neutrophil activation involved in immune response

IEA

regulation of platelet activation

immunoglobulin mediated immune response

3 references

14 February 2019

IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

antigen processing and presentation of exogenous peptide antigen via MHC class II

Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice

neutrophil chemotaxis

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Cutting edge: Fc receptor type I for IgG on macrophages and complement mediate the inflammatory response in immune complex peritonitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

antigen processing and presentation of exogenous peptide antigen via MHC class I

C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor

innate immune response

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

positive regulation of phagocytosis

4 references

14 February 2019

FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Targeting to Fcgamma receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20491

Phosphorylated immunoreceptor signalling ITAM

has part(s)

1 reference

stated in

InterPro Release 71.0