(Q21495748)

http://www.ebi.ac.uk/interpro/protein/Q8BTM8

Immunoglobulin-like fold

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BTM8

Immunoglobulin E-set

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8BTM8

Calponin homology domain, protein family

1 reference

Actinin-type actin-binding domain, conserved site, protein family

1 reference

Filamin/ABP280 repeat, protein family

1 reference

Filamin/ABP280 repeat-like, protein family

1 reference

protein homodimerization activity

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

G protein-coupled receptor binding

actin filament binding

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

The F-actin cross-linking and focal adhesion protein filamin A is a ligand and in vivo substrate for protein kinase C alpha

protein kinase C binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

transcription factor binding

IDA

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

transmembrane transporter binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTM8&geneProductId=UniProtKB:Q8BTM8

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

14 February 2019

The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

14 February 2019

Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

14 February 2019

Calsarcins, a novel family of sarcomeric calcineurin-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

14 February 2019

Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

14 February 2019

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

14 February 2019

The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

14 February 2019

Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

14 February 2019

Bioinformatics and cellular signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

mu-type opioid receptor binding

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

protein-containing complex binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements

actin filament bundle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

2 references

3 references

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTM8&geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

A B-Myb complex containing clathrin and filamin is required for mitotic spindle function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

2 references

1 reference

14 February 2019

Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

cortical cytoskeleton

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

protein-containing complex

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BTM8&geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

perinuclear region of cytoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

glutamatergic synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

positive regulation of substrate adhesion-dependent cell spreading

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

A B-Myb complex containing clathrin and filamin is required for mitotic spindle function

mitotic spindle assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

actin cytoskeleton organization

1 reference

14 February 2019

RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

epithelial to mesenchymal transition

IGI

1 reference

14 February 2019

RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

negative regulation of transcription by RNA polymerase I

IGI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

actin cytoskeleton reorganization

2 references

protein stabilization

Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis

2 references

blood vessel remodeling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

cell-cell junction organization

1 reference

14 February 2019

Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

cell projection organization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

actin crosslink formation

IEA

2 references

2 references

positive regulation of integrin-mediated signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

early endosome to late endosome transport

1 reference

14 February 2019

Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

negative regulation of apoptotic process

IDA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

regulation of actin filament bundle assembly

1 reference

14 February 2019

A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

negative regulation of neuron projection development

1 reference

14 February 2019

Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

wound healing, spreading of cells

IGI

regulation of cell migration

2 references

semaphorin-plexin signaling pathway

2 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

14 February 2019

Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

14 February 2019

Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

regulation of membrane repolarization during atrial cardiac muscle cell action potential

1 reference

14 February 2019

Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

regulation of membrane repolarization during cardiac muscle cell action potential

IC

1 reference

14 February 2019

Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

formation of radial glial scaffolds

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

mRNA transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

positive regulation of neural precursor cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

positive regulation of neuron migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

positive regulation of actin filament bundle assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

establishment of Sertoli cell barrier

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8

protein localization to bicellular tight junction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BTM8