(Q21496113)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48985

Helix-loop-helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48985

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

1 reference

14 February 2019

DNA-binding transcription activator activity, RNA polymerase II-specific

2 references

24 April 2018

Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48985&geneProductId=UniProtKB:P48985

14 February 2019

Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

protein binding

IPI

chromatin DNA binding

1 reference

14 February 2019

Commissural neuron identity is specified by a homeodomain protein, Mbh1, that is directly downstream of Math1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

biological process

Notch signaling pathway

1 reference

14 February 2019

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

regulation of neuron differentiation

1 reference

14 February 2019

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

auditory receptor cell fate determination

1 reference

14 February 2019

Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

positive regulation of inner ear auditory receptor cell differentiation

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

1 reference

14 February 2019

positive regulation of inner ear receptor cell differentiation

negative regulation of apoptotic process

1 reference

14 February 2019

The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

neuron migration

1 reference

14 February 2019

Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48985&geneProductId=UniProtKB:P48985

1 reference

24 April 2018

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

1 reference

14 February 2019

auditory receptor cell fate specification

1 reference

14 February 2019

Math1: an essential gene for the generation of inner ear hair cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

axon guidance

1 reference

14 February 2019

Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

1 reference

14 February 2019

brain development

1 reference

14 February 2019

Dissection of the cellular and molecular events that position cerebellar Purkinje cells: a study of the math1 null-mutant mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

inner ear auditory receptor cell differentiation

The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

14 February 2019

Math1 regulates development of the sensory epithelium in the mammalian cochlea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

14 February 2019

14 February 2019

Math1 regulates development of the sensory epithelium in the mammalian cochlea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

positive regulation of neuron differentiation

1 reference

14 February 2019

Generation of neurons by transient expression of neural bHLH proteins in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

cerebral cortex development

1 reference

14 February 2019

A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

inner ear development

1 reference

14 February 2019

Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

positive regulation of transcription by RNA polymerase II

Commissural neuron identity is specified by a homeodomain protein, Mbh1, that is directly downstream of Math1

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

14 February 2019

A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

14 February 2019

Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

14 February 2019

Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48985

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48985&geneProductId=UniProtKB:P48985

Myc-type, basic helix-loop-helix (bHLH) domain

has part(s)

1 reference

InterPro Release 71.0