(Q21496151)

http://www.ebi.ac.uk/interpro/protein/Q61188

SANT/Myb domain, protein family

1 reference

Tesmin/TSO1-like CXC domain, protein family

1 reference

CXC domain, protein family

1 reference

SET domain, protein family

1 reference

methyltransferase activity

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

histone methyltransferase activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

sequence-specific DNA binding

1 reference

14 February 2019

STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

primary miRNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

histone-lysine N-methyltransferase activity

4 references

14 February 2019

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

protein-lysine N-methyltransferase activity

1 reference

14 February 2019

Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

12 references

14 February 2019

The polycomb group protein EZH2 is required for mammalian circadian clock function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Juxtaposed Polycomb complexes co-regulate vertebral identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Jarid2 regulates mouse epidermal stem cell activation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

BRCA1 is a negative modulator of the PRC2 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Point mutations in the WD40 domain of Eed block its interaction with Ezh2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

3 references

14 February 2019

Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

ribonucleoprotein complex binding

1 reference

14 February 2019

Genome-wide identification of polycomb-associated RNAs by RIP-seq

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

chromatin DNA binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

promoter-specific chromatin binding

3 references

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

24 April 2018

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61188&geneProductId=UniProtKB:Q61188

RNA polymerase II core promoter sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

transcription corepressor activity

1 reference

14 February 2019

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

1 reference

14 February 2019

Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

9 references

14 February 2019

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Epiblast stem cell-based system reveals reprogramming synergy of germline factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

regulation of protein phosphorylation

biological process

1 reference

14 February 2019

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

regulation of gliogenesis

1 reference

14 February 2019

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

response to estradiol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

regulation of transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61188&geneProductId=UniProtKB:Q61188

positive regulation of MAP kinase activity

3 references

histone H3-K27 trimethylation

1 reference

14 February 2019

The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

negative regulation of retinoic acid receptor signaling pathway

3 references

negative regulation of striated muscle cell differentiation

1 reference

14 February 2019

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

1 reference

14 February 2019

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration

hepatocyte homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

negative regulation of transcription by RNA polymerase II

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

positive regulation of epithelial to mesenchymal transition

3 references

transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61188&geneProductId=UniProtKB:Q61188

negative regulation of transcription elongation from RNA polymerase II promoter

1 reference

14 February 2019

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

negative regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

positive regulation of protein serine/threonine kinase activity

3 references

cellular response to trichostatin A

1 reference

14 February 2019

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

negative regulation of G1/S transition of mitotic cell cycle

1 reference

14 February 2019

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

histone H3-K27 methylation

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

The polycomb group protein EZH2 is required for mammalian circadian clock function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

positive regulation of GTPase activity

3 references

1 reference

14 February 2019

Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

negative regulation of epidermal cell differentiation

1 reference

14 February 2019

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

1 reference

14 February 2019

The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

negative regulation of gene expression, epigenetic

3 references

cardiac muscle hypertrophy in response to stress

1 reference

14 February 2019

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

regulation of cell population proliferation

1 reference

14 February 2019

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

regulation of circadian rhythm

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

The polycomb group protein EZH2 is required for mammalian circadian clock function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration

1 reference

14 February 2019

Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

cerebellar cortex development

1 reference

14 February 2019

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

regulation of gene expression

response to tetrachloromethane

1 reference

14 February 2019

The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

negative regulation of transcription, DNA-templated

3 references

protein localization to chromatin

1 reference

14 February 2019

PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

hippocampus development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

regulation of neurogenesis

1 reference

14 February 2019

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

cellular response to hydrogen peroxide

1 reference

14 February 2019

A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

14 February 2019

Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188

chromatin organization

1 reference

14 February 2019

positive regulation of cell population proliferation

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61188&geneProductId=UniProtKB:Q61188

positive regulation of cell cycle G1/S phase transition

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61188&geneProductId=UniProtKB:Q61188