(Q21496570)

English

Leptin receptor

mammalian protein found in Mus musculus

Lepr
B219
OB receptor
leptin receptor
LEP-R
OB-R
leptin receptor gene-related protein

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Fibronectin type III superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48356

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48356

leptin receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48356

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Fibronectin type III, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin C2-set-like, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Short hematopoietin receptor, family 1, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method

5 references

14 February 2019

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

14 February 2019

Analysis of leptin signalling in hematopoietic cells using an adapted MAPPIT strategy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

14 February 2019

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

14 February 2019

Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

14 February 2019

Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

cytokine receptor activity

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48356&geneProductId=UniProtKB:P48356

determination method

transmembrane signaling receptor activity

determination method

1 reference

14 February 2019

The leptin receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

protein-hormone receptor activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

peptide hormone binding

determination method

1 reference

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48356&geneProductId=UniProtKB:P48356

determination method

cytokine binding

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

integral component of membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

determination method

2 references

integral component of plasma membrane

determination method

1 reference

14 February 2019

The leptin receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

extracellular region

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

basolateral plasma membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

extracellular space

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

plasma membrane

determination method

3 references

external side of plasma membrane

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

receptor complex

determination method

3 references

14 February 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

biological process

sexual reproduction

determination method

1 reference

14 February 2019

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

cholesterol metabolic process

determination method

1 reference

14 February 2019

Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

negative regulation of hydrolase activity

determination method

1 reference

14 February 2019

Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

regulation of feeding behavior

determination method

1 reference

14 February 2019

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

negative regulation of gluconeogenesis

determination method

1 reference

14 February 2019

Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

T cell differentiation

determination method

1 reference

14 February 2019

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

determination method

1 reference

14 February 2019

Leptin regulates proinflammatory immune responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

determination method

1 reference

14 February 2019

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

regulation of metabolic process

determination method

1 reference

14 February 2019

The leptin receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

response to leptin

determination method

1 reference

14 February 2019

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

signal transduction

determination method

1 reference

14 February 2019

The leptin receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

regulation of bone remodeling

determination method

1 reference

14 February 2019

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

negative regulation of autophagy

determination method

3 references

determination method

3 references

positive regulation of insulin secretion involved in cellular response to glucose stimulus

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

eating behavior

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

positive regulation of MAPK cascade

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

negative regulation of eating behavior

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

negative regulation of locomotor rhythm

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

leptin-mediated signaling pathway

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

14 February 2019

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

positive regulation of cold-induced thermogenesis

determination method

1 reference

14 February 2019

Impaired response of UCP family to cold exposure in diabetic (db/db) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

glycogen metabolic process

determination method

1 reference

14 February 2019

Suppression of leptin signaling reduces polyglucosan inclusions and seizure susceptibility in a mouse model for Lafora disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

glial cell proliferation

determination method

1 reference

14 February 2019

Suppression of leptin signaling reduces polyglucosan inclusions and seizure susceptibility in a mouse model for Lafora disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48356

determination method

Short hematopoietin receptor, family 1, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48356

fibronectin type III

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48356

immunoglobulin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48356

Immunoglobulin C2-set-like, ligand-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48356

Long hematopoietin receptor, Gp130 family 2, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48356

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000037385

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000037385

ENSMUSP00000099838

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000099838

ENSMUSP00000102534

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000102534

ENSMUSP00000123654

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000123654

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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