(Q47705895)

5 February 2018

title

Suppression of leptin signaling reduces polyglucosan inclusions and seizure susceptibility in a mouse model for Lafora disease (English)

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5 February 2018

main subject

Leptin receptor

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Epilepsy, progressive myoclonic epilepsy, type 2 gene alpha

GOA release 2020-03-11

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GOA release 2020-03-11

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Anupama Rai

1

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5 February 2018

Rohit Mishra

series ordinal

2

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5 February 2018

Subramaniam Ganesh

series ordinal

3

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5 February 2018

publication date

14 September 2017

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5 February 2018

published in

Human Molecular Genetics

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5 February 2018

volume

26

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5 February 2018

issue

24

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5 February 2018

page(s)

4778-4785

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5 February 2018

22-year-old girl with status epilepticus and progressive neurological symptoms

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Glycogen phosphorylation and Lafora disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Glycogen hyperphosphorylation underlies lafora body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Recent advances in the molecular basis of Lafora's progressive myoclonus epilepsy.

21 January 2018

1 reference

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Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

The laforin-malin complex negatively regulates glycogen synthesis by modulating cellular glucose uptake via glucose transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Leptin and the central nervous system control of glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase- dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor

21 January 2018

1 reference

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Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

21 January 2018

1 reference

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Glycogen metabolism in tissues from a mouse model of Lafora disease

21 January 2018

1 reference

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Progressive familial myoclonic epilepsy with Lafora bodies. Electron microscopic and histochemical study of a cerebral biopsy.

21 January 2018

1 reference

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Dysfunctions in endosomal-lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease.

21 January 2018

1 reference

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Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease

21 January 2018

1 reference

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Inflammation in Lafora Disease: Evolution with Disease Progression in Laforin and Malin Knock-out Mouse Models

21 January 2018

1 reference

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Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy

21 January 2018

1 reference

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Biochemical studies on tissues from a patient with lafora disease

21 January 2018

1 reference

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Studies in myoclonus epilepsy (Lafora body form). I. Isolation and preliminary characterization of Lafora bodies in two cases.

21 January 2018

1 reference

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Central nervous system control of food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Sodium selenate treatment improves symptoms and seizure susceptibility in a malin-deficient mouse model of Lafora disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Leptin potentiates astrogenesis in the developing hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Brain glycogen in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Deciphering the role of malin in the lafora progressive myoclonus epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Novel superactive leptin antagonists and their potential therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Decreased O-linked GlcNAcylation protects from cytotoxicity mediated by huntingtin exon1 protein fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Activation of serum/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

Acute stimulation of glucose metabolism in mice by leptin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX357

21 January 2018

Identifiers

DOI

10.1093/HMG/DDX357

1 reference

5 February 2018

1 reference

5 February 2018