(Q21496861)

Homeobox protein SIX3

1 reference

stated in

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox protein SIX1, N-terminal SD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Six3 activation of Pax6 expression is essential for mammalian lens induction and specification

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

sequence-specific DNA binding

1 reference

14 February 2019

Identification and expression of six family genes in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

DNA-binding transcription factor activity

1 reference

14 February 2019

Repression of Six3 by a corepressor regulates rhodopsin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

transcription coactivator activity

1 reference

14 February 2019

Repression of Six3 by a corepressor regulates rhodopsin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

histone deacetylase binding

1 reference

14 February 2019

Repression of Six3 by a corepressor regulates rhodopsin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

DNA-binding transcription activator activity, RNA polymerase II-specific

IPI

2 references

5 references

14 February 2019

EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Repression of Six3 by a corepressor regulates rhodopsin expression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

IPI

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

transcription corepressor binding

3 references

transcription cis-regulatory region binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

10 September 2018

Six3 activation of Pax6 expression is essential for mammalian lens induction and specification

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

1 January 2018

Six3 activation of Pax6 expression is essential for mammalian lens induction and specification

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

7 November 2018

Six3 activation of Pax6 expression is essential for mammalian lens induction and specification

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

7 November 2018

Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

DNA-binding transcription factor activity, RNA polymerase II-specific

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Six3 activation of Pax6 expression is essential for mammalian lens induction and specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

24 April 2018

Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

24 April 2018

Identification and expression of six family genes in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

24 April 2018

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Identification and expression of six family genes in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

transcription regulator complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

24 April 2018

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

forebrain anterior/posterior pattern specification

IGI

pituitary gland development

1 reference

14 February 2019

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

negative regulation of neuron differentiation

1 reference

14 February 2019

Six3 controls the neural progenitor status in the murine CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

proximal/distal axis specification

1 reference

14 February 2019

Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

lens fiber cell apoptotic process

1 reference

14 February 2019

Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

protein import into nucleus

1 reference

14 February 2019

Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

neuroblast differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

forebrain dorsal/ventral pattern formation

3 references

optic vesicle morphogenesis

1 reference

14 February 2019

Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

negative regulation of Wnt signaling pathway

1 reference

14 February 2019

Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

apoptotic process involved in development

1 reference

14 February 2019

Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

regulation of neural precursor cell proliferation

1 reference

14 February 2019

Six3 controls the neural progenitor status in the murine CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

regulation of neural retina development

1 reference

14 February 2019

Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

telencephalon regionalization

1 reference

14 February 2019

Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon

diencephalon development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

telencephalon development

IGI

lens development in camera-type eye

1 reference

14 February 2019

Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

lens fiber cell differentiation

1 reference

14 February 2019

Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

regulation of cell population proliferation

1 reference

14 February 2019

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

regulation of neuroblast proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

lens induction in camera-type eye

1 reference

14 February 2019

Six3 activation of Pax6 expression is essential for mammalian lens induction and specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

epithelial cell maturation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

1 reference

14 February 2019

Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

camera-type eye development

1 reference

14 February 2019

Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

negative regulation of transcription, DNA-templated

IGI

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

24 April 2018

Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

24 April 2018

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

cell proliferation in forebrain

1 reference

14 February 2019

Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

positive regulation of transcription by RNA polymerase II

regulation of cell cycle phase transition

1 reference

14 February 2019

Six3 controls the neural progenitor status in the murine CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

3 references

14 February 2019

Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

negative regulation of transcription, DNA-templated

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

anatomical structure development

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233

1 reference

Homeobox protein SIX1, N-terminal SD domain

1 reference

stated in