(Q21497189)

Calpain large subunit, domain III superfamily

1 reference

EF-hand domain pair

1 reference

Papain-like cysteine peptidase superfamily

1 reference

EF-hand domain, protein family

1 reference

Peptidase C2, calpain, large subunit, domain III, protein family

1 reference

Peptidase C2, calpain, domain III, protein family

1 reference

Calpain subdomain III, protein family

1 reference

Peptidase C2, calpain, catalytic domain, protein family

1 reference

Cysteine peptidase, cysteine active site, protein family

1 reference

EF-Hand 1, calcium-binding site, protein family

1 reference

cysteine-type peptidase activity

1 reference

10 April 2019

1 reference

10 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

1 reference

8 April 2019

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

3 references

8 April 2019

Dysferlin interacts with tubulin and microtubules in mouse skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

molecular adaptor activity

IPI

structural constituent of muscle

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

ligase regulator activity

calcium-dependent cysteine-type endopeptidase activity

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

signaling receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

calcium-dependent cysteine-type endopeptidase activity

ISO

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

6 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

intracellular anatomical structure

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

protein-containing complex

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

muscle structure development

IBA

biological process

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

cellular response to calcium ion

1 reference

8 April 2019

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

protein localization to membrane

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

negative regulation of protein sumoylation

positive regulation of satellite cell activation involved in skeletal muscle regeneration

1 reference

8 April 2019

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

negative regulation of apoptotic process

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

positive regulation of release of sequestered calcium ion into cytosol

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

6 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

16 July 2018

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

positive regulation of transcription, DNA-templated

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

negative regulation of skeletal muscle cell differentiation

1 reference

16 July 2018

Rbfox1 downregulation and altered calpain 3 splicing by FRG1 in a mouse model of Facioscapulohumeral muscular dystrophy (FSHD)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

G1 to G0 transition involved in cell differentiation

1 reference

8 April 2019

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

cellular response to salt stress

1 reference

8 April 2019

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

1 reference

8 April 2019

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

regulation of myoblast differentiation

1 reference

8 April 2019

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

positive regulation of NF-kappaB transcription factor activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

positive regulation of proteolysis

1 reference

8 April 2019

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

regulation of catalytic activity

negative regulation of transcription, DNA-templated

1 reference

8 April 2019

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

regulation of I-kappaB kinase/NF-kappaB signaling

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease

programmed cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

protein-containing complex assembly

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

sodium-dependent self proteolysis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

protein catabolic process

ISO

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

protein destabilization

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

negative regulation of apoptotic process

IBA

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

calcium-dependent self proteolysis

IBA

Peptidase C2, calpain, catalytic domain

1 reference

Peptidase C2, calpain, large subunit, domain III

1 reference

EF-hand 1, calcium-binding site

1 reference

Peptidase C2, calpain, domain III

1 reference

EF-hand domain

1 reference

Cysteine peptidase, cysteine active site

1 reference

Calpain subdomain III

1 reference