(Q21497809)

http://www.ebi.ac.uk/interpro/protein/P23772

Transcription factor GATA-3

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23772

Zinc finger, GATA-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein dimerization activity

1 reference

14 February 2019

Crystal Structures of Multiple GATA Zinc Fingers Bound to DNA Reveal New Insights into DNA Recognition and Self-Association by GATA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

6 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

cis-regulatory region sequence-specific DNA binding

3 references

interleukin-2 receptor binding

1 reference

14 February 2019

ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

6 references

14 February 2019

Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

transcription coactivator activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

transcription cis-regulatory region binding

3 references

3 references

cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

sequence-specific DNA binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Crystal Structures of Multiple GATA Zinc Fingers Bound to DNA Reveal New Insights into DNA Recognition and Self-Association by GATA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

RNA polymerase II cis-regulatory region sequence-specific DNA binding

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

5 June 2018

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

5 June 2018

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

core promoter sequence-specific DNA binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

RNA polymerase II cis-regulatory region sequence-specific DNA binding

ISO

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

21 June 2018

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

21 June 2018

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

transcription coregulator activity

1 reference

14 February 2019

GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

RNA polymerase II cis-regulatory region sequence-specific DNA binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription factor activity

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

10 September 2018

Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

transcription coactivator activity

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

10 references

21 June 2018

Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

21 June 2018

TCR-dependent translational control of GATA-3 enhances Th2 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

21 June 2018

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

21 June 2018

GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

21 June 2018

GATA-3: an unexpected regulator of cell lineage determination in skin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

21 June 2018

GATA3 is downregulated during hair cell differentiation in the mouse cochlea

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

21 June 2018

Gata3 is a critical regulator of cochlear wiring

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

transcription regulator complex

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

11 references

14 February 2019

Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

TCR-dependent translational control of GATA-3 enhances Th2 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

GATA3 is downregulated during hair cell differentiation in the mouse cochlea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Gata3 is a critical regulator of cochlear wiring

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

GATA-3: an unexpected regulator of cell lineage determination in skin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

positive regulation of transcription regulatory region DNA binding

biological process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation

1 reference

14 February 2019

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

positive regulation of interleukin-5 production

1 reference

14 February 2019

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

regulation of neuron projection development

1 reference

14 February 2019

Gata3 is a critical regulator of cochlear wiring

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

T cell differentiation in thymus

4 references

14 February 2019

GATA-3 is required for early T lineage progenitor development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Transcription factor GATA-3 is required for development of the T-cell lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Critical roles for transcription factor GATA-3 in thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

regulation of transcription by RNA polymerase II

IGI

5 references

14 February 2019

Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

aortic valve morphogenesis

1 reference

14 February 2019

Lack of Gata3 results in conotruncal heart anomalies in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

anatomical structure formation involved in morphogenesis

1 reference

14 February 2019

Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

negative regulation of cell motility

3 references

negative regulation of cell cycle

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Transcription factor GATA-3 is essential for lens development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

3 references

post-embryonic development

1 reference

14 February 2019

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

regulation of CD4-positive, alpha-beta T cell differentiation

1 reference

14 February 2019

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

cellular response to cytokine stimulus

1 reference

14 February 2019

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney

mesonephros development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

negative regulation of DNA demethylation

positive regulation of thyroid hormone generation

2 references

3 references

humoral immune response

1 reference

14 February 2019

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

3 references

phosphatidylinositol 3-kinase signaling

1 reference

14 February 2019

TCR-dependent translational control of GATA-3 enhances Th2 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

regulation of histone H3-K27 methylation

1 reference

14 February 2019

Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

negative regulation of inflammatory response

3 references

pharyngeal system development

1 reference

14 February 2019

Lack of Gata3 results in conotruncal heart anomalies in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

negative regulation of endothelial cell apoptotic process

3 references

renal system development

1 reference

1 January 2018

Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

2 references

positive regulation of signal transduction

3 references

negative regulation of fat cell differentiation

3 references

positive regulation of protein kinase B signaling

3 references

type IV hypersensitivity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

ventricular septum development

1 reference

14 February 2019

Lack of Gata3 results in conotruncal heart anomalies in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

positive regulation of histone H3-K9 acetylation

T-helper 2 cell differentiation

2 references

1 reference

14 February 2019

The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

embryonic organ development

1 reference

1 January 2018

Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

regulation of neuron apoptotic process

1 reference

14 February 2019

The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

regulation of histone H3-K4 methylation

1 reference

14 February 2019

Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

in utero embryonic development

1 reference

14 February 2019

The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

GATA-3 regulates the development and function of invariant NKT cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

negative regulation of gene expression

1 reference

14 February 2019

GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

transcription, DNA-templated

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 reference

14 February 2019

GATA-3 regulates the development and function of invariant NKT cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

positive regulation of transcription, DNA-templated

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

regulation of cellular response to X-ray

3 references

1 reference

14 February 2019

TCR-dependent translational control of GATA-3 enhances Th2 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

parathyroid gland development

1 reference

14 February 2019

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation

1 reference

14 February 2019

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

positive regulation of cell differentiation

1 reference

14 February 2019

Transcription factor GATA-3 is essential for lens development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

erythrocyte differentiation

1 reference

14 February 2019

Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

innate immune response

1 reference

14 February 2019

response to gamma radiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

regulation of nephron tubule epithelial cell differentiation

1 reference

14 February 2019

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction

male gonad development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

norepinephrine biosynthetic process

1 reference

14 February 2019

Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

immune system process

1 reference

14 February 2019

parathyroid hormone secretion

1 reference

14 February 2019

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney

nephric duct formation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

nervous system development

1 reference

14 February 2019

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

nephric duct morphogenesis

1 reference

14 February 2019

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

Pet-1 is required across different stages of life to regulate serotonergic function.

neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney

ureteric bud formation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

cellular response to interferon-alpha

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

canonical Wnt signaling pathway involved in metanephric kidney development

1 reference

14 February 2019

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

positive regulation of T-helper 2 cell cytokine production

1 reference

14 February 2019

Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

negative regulation of transcription, DNA-templated

3 references

regulation of establishment of cell polarity

1 reference

14 February 2019

Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

positive regulation of histone H3-K14 acetylation

cellular response to interleukin-4

2 references

3 references

14 February 2019

TCR-dependent translational control of GATA-3 enhances Th2 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

negative regulation of interferon-gamma production

sympathetic nervous system development

1 reference

14 February 2019

Essential role of Gata transcription factors in sympathetic neuron development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

homeostasis of number of cells

1 reference

14 February 2019

GATA-3 is required for early T lineage progenitor development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

positive regulation of cytokine production

1 reference

14 February 2019

Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

negative regulation of cell proliferation involved in mesonephros development

1 reference

14 February 2019

Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

pro-T cell differentiation

1 reference

14 February 2019

GATA-3 is required for early T lineage progenitor development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

cellular response to tumor necrosis factor

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

cellular response to BMP stimulus

1 reference

14 February 2019

Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear

otic vesicle development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

positive regulation of endothelial cell migration

3 references

positive regulation of interleukin-13 production

1 reference

14 February 2019

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

positive regulation of gene expression

1 reference

14 February 2019

Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

lens development in camera-type eye

IGI

1 reference

14 February 2019

Transcription factor GATA-3 is essential for lens development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

Transcription factor GATA-3 is required for development of the T-cell lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

positive regulation of ureteric bud formation

1 reference

14 February 2019

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

GATA-3: an unexpected regulator of cell lineage determination in skin

cell fate determination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

mast cell differentiation

1 reference

14 February 2019

Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

T cell receptor signaling pathway

1 reference

14 February 2019

TCR-dependent translational control of GATA-3 enhances Th2 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

negative regulation of interleukin-2 production

1 reference

14 February 2019

Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

cardiac right ventricle morphogenesis

1 reference

14 February 2019

Lack of Gata3 results in conotruncal heart anomalies in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

Critical roles for transcription factor GATA-3 in thymocyte development

thymic T cell selection

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

positive regulation of transcription by RNA polymerase II

12 references

14 February 2019

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

14 February 2019

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

mesenchymal to epithelial transition

3 references

transcription by RNA polymerase II

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

animal organ morphogenesis

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

anatomical structure formation involved in morphogenesis

negative regulation of cell cycle

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

Transcription factor GATA-3 is essential for lens development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

negative regulation of transcription, DNA-templated

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

cellular response to interleukin-4

4 references

1 January 2018

TCR-dependent translational control of GATA-3 enhances Th2 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

positive regulation of transcription regulatory region DNA binding

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

digestive tract development

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772

immune system development

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

regulation of epithelial cell differentiation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

1 reference

14 February 2019

Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772

IGI

has part(s)

Zinc finger, GATA-type

1 reference

stated in

InterPro Release 71.0