(Q21498459)

http://www.ebi.ac.uk/interpro/protein/Q9Z2I2

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

FKBP

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

transmembrane transporter binding

3 references

9 May 2019

Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

peptidyl-prolyl cis-trans isomerase activity

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2I2&geneProductId=UniProtKB:Q9Z2I2

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2I2&geneProductId=UniProtKB:Q9Z2I2

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2I2&geneProductId=UniProtKB:Q9Z2I2

24 April 2018

Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2I2&geneProductId=UniProtKB:Q9Z2I2

peptidyl-prolyl cis-trans isomerase activity

IDA

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2I2&geneProductId=UniProtKB:Q9Z2I2

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2I2&geneProductId=UniProtKB:Q9Z2I2

10 September 2018

FKBP12.6 and cADPR regulation of Ca2+release in smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2I2&geneProductId=UniProtKB:Q9Z2I2

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2I2&geneProductId=UniProtKB:Q9Z2I2

calcium channel complex

3 references

sarcoplasmic reticulum

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

sarcoplasmic reticulum membrane

IBA

3 references

9 May 2019

Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

FKBP12.6 and cADPR regulation of Ca2+release in smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

smooth muscle contraction

IBA

biological process

1 reference

9 May 2019

FKBP12.6 and cADPR regulation of Ca2+release in smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

regulation of ryanodine-sensitive calcium-release channel activity

release of sequestered calcium ion into cytosol

2 references

1 reference

9 May 2019

RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

regulation of cytosolic calcium ion concentration

3 references

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

1 reference

24 April 2018

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2I2&geneProductId=UniProtKB:Q9Z2I2

negative regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

9 May 2019

FKBP12.6-knockout mice display hyperinsulinemia and resistance to high-fat diet-induced hyperglycemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

1 reference

9 May 2019

FKBP12.6 disruption impairs glucose-induced insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

1 reference

9 May 2019

FKBP12.6 disruption impairs glucose-induced insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

response to organic substance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

negative regulation of heart rate

1 reference

9 May 2019

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias

regulation of heart rate

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

negative regulation of ryanodine-sensitive calcium-release channel activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

ISO

response to vitamin E

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

1 reference

9 May 2019

Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

neuronal action potential propagation

1 reference

9 May 2019

Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

FKBP12.6 and cADPR regulation of Ca2+release in smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

response to hydrogen peroxide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

chaperone-mediated protein folding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2I2

positive regulation of cytosolic calcium ion concentration

IBA

3 references

protein peptidyl-prolyl isomerization

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

FKBP-type peptidyl-prolyl cis-trans isomerase domain

1 reference

stated in

InterPro Release 71.0