(Q21498889)

http://www.ebi.ac.uk/interpro/protein/Q4VGL6

Roquin-1

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q4VGL6

Zinc finger, RING/FYVE/PHD-type

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q4VGL6

RING-type zinc-finger, LisH dimerisation motif, protein family

1 reference

Zinc finger, RING-type, protein family

1 reference

Zinc finger, CCCH-type, protein family

1 reference

Zinc finger, RING-type, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

1 reference

25 May 2022

1 reference

25 May 2022

2 references

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

3 references

14 February 2019

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

1 reference

14 February 2019

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

1 reference

14 February 2019

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

1 reference

14 February 2019

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

RNA stem-loop binding

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4VGL6&geneProductId=UniProtKB:Q4VGL6

24 April 2018

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4VGL6&geneProductId=UniProtKB:Q4VGL6

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4VGL6&geneProductId=UniProtKB:Q4VGL6

24 April 2018

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4VGL6&geneProductId=UniProtKB:Q4VGL6

double-stranded RNA binding

3 references

ubiquitin-protein transferase activity

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

RNA stem-loop binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

cytoplasmic stress granule

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

regulation of T cell proliferation

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

regulation of T cell activation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

regulation of mRNA stability

1 reference

14 February 2019

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

regulation of T cell receptor signaling pathway

1 reference

14 February 2019

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

1 reference

14 February 2019

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

1 reference

14 February 2019

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

positive regulation of NIK/NF-kappaB signaling

1 reference

14 February 2019

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

1 reference

14 February 2019

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

1 reference

14 February 2019

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

negative regulation of activated T cell proliferation

1 reference

14 February 2019

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

cellular response to interleukin-1

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

1 reference

14 February 2019

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

negative regulation of germinal center formation

1 reference

14 February 2019

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

posttranscriptional regulation of gene expression

4 references

14 February 2019

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

regulation of gene expression

1 reference

14 February 2019

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

lymph node development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

negative regulation of B cell proliferation

1 reference

14 February 2019

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

T follicular helper cell differentiation

1 reference

14 February 2019

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

negative regulation of T-helper cell differentiation

1 reference

14 February 2019

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

nuclear-transcribed mRNA catabolic process

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4VGL6&geneProductId=UniProtKB:Q4VGL6

24 April 2018

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4VGL6&geneProductId=UniProtKB:Q4VGL6

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q4VGL6&geneProductId=UniProtKB:Q4VGL6

T cell receptor signaling pathway

1 reference

14 February 2019

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

positive regulation of mRNA catabolic process

3 references

14 February 2019

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

negative regulation of T-helper 17 cell differentiation

1 reference

14 February 2019

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

regulation of miRNA metabolic process

1 reference

14 February 2019

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

protein polyubiquitination

3 references

nuclear-transcribed mRNA catabolic process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q4VGL6

protein ubiquitination

1 reference

14 February 2019

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016