(Q21499071)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q925H0

acid-sensing ion channel 2

1 reference

Transporter Classification Database ID

1.A.6.1.8

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

Epithelial sodium channel, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

sodium channel activity

2 references

1 reference

14 February 2019

ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

ligand-gated sodium channel activity

IPI

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

14 February 2019

A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

14 February 2019

Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

voltage-gated sodium channel activity

IDA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

integral component of membrane

ISO

cell component

3 references

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

1 reference

14 February 2019

ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

1 reference

14 February 2019

ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

1 reference

14 February 2019

Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

1 reference

14 February 2019

Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

positive regulation of synapse assembly

IDA

biological process

1 reference

14 February 2019

ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

detection of mechanical stimulus involved in sensory perception

1 reference

14 February 2019

The mammalian sodium channel BNC1 is required for normal touch sensation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

regulation of membrane potential

1 reference

14 February 2019

ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

regulation of ion transmembrane transport

1 reference

14 February 2019

Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

response to mechanical stimulus

1 reference

14 February 2019

The mammalian sodium channel BNC1 is required for normal touch sensation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

negative regulation of apoptotic process

1 reference

14 February 2019

Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

sensory perception of sound

IEA

1 reference

14 February 2019

Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

regulation of vasoconstriction

1 reference

14 February 2019

Impaired pressure-induced constriction in mouse middle cerebral arteries of ASIC2 knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

protein localization to synapse

1 reference

14 February 2019

ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons

response to acidic pH

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

14 February 2019

Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

14 February 2019

Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

1 reference

14 February 2019

Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback

1 reference

14 February 2019

The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

sodium ion transmembrane transport

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

cation transmembrane transport

IEA

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

ion transmembrane transport

IEA

5 references

14 February 2019

Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

14 February 2019

ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

14 February 2019

Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

14 February 2019

Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

14 February 2019

Acid sensing ion channels in dorsal spinal cord neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

14 February 2019

A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

14 February 2019

Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

cellular response to acidic pH

IDA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

positive regulation of cation channel activity

ISO

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q925H0

Epithelial sodium channel, conserved site

ISO

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q925H0

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

Transporter Classification Database ID

1.A.6.1.8

2 references

Transporter Classification database

retrieved

13 March 2020