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(Q21499271)
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Cytokine inducible SH2-containing protein
mammalian protein found in Mus musculus
cytokine-inducible SH2 protein
cytokine-inducible SH2-containing protein
Cish
suppressor of cytokine signaling
CIS-1
SOCS
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q62225
subclass of
protein
1 reference
stated in
UniProt
retrieved
19 January 2017
UniProt protein ID
Q62225
part of
Cytokine-inducible SH2-containing protein
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q62225
SOCS box-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q62225
SH2 domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q62225
SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
CIS, SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SOCS box domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q62225
encoded by
Cish
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q62225
molecular function
protein kinase inhibitor activity
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62225&geneProductId=UniProtKB:Q62225
determination method
IBA
protein binding
determination method
IPI
3 references
retrieved
14 February 2019
stated in
Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IPI
retrieved
14 February 2019
stated in
A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IPI
retrieved
14 February 2019
stated in
Design and application of a cytokine-receptor-based interaction trap
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IPI
1-phosphatidylinositol-3-kinase regulator activity
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IBA
cell component
plasma membrane
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IDA
cytoplasm
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62225&geneProductId=UniProtKB:Q62225
determination method
IBA
intracellular anatomical structure
determination method
IEA
1 reference
retrieved
10 September 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62225&geneProductId=UniProtKB:Q62225
determination method
IEA
phosphatidylinositol 3-kinase complex
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IBA
biological process
negative regulation of insulin receptor signaling pathway
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IBA
negative regulation of receptor signaling pathway via JAK-STAT
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62225&geneProductId=UniProtKB:Q62225
determination method
IBA
intracellular signal transduction
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IEA
negative regulation of protein kinase activity
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62225&geneProductId=UniProtKB:Q62225
determination method
IBA
protein kinase C-activating G protein-coupled receptor signaling pathway
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IDA
regulation of growth
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62225
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IEA
protein ubiquitination
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62225
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IEA
negative regulation of signal transduction
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62225
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IEA
cytokine-mediated signaling pathway
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62225&geneProductId=UniProtKB:Q62225
determination method
IBA
regulation of phosphatidylinositol 3-kinase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IEA
phosphatidylinositol phosphate biosynthetic process
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62225
determination method
IBA
has part(s)
SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q62225
SOCS box domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q62225
CIS, SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q62225
Identifiers
RefSeq protein ID
NP_001304283
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
12700
NP_034025
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
12700
XP_006511698
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
12700
UniProt protein ID
Q62225
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q62225
Ensembl protein ID
ENSMUSP00000082183
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000082183
ENSMUSP00000127523
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000127523
ENSMUSP00000129941
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000129941
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