(Q21499474)

English

Axin 2

mammalian protein found in Mus musculus

axin-like protein
Axin2
Axil
axin-2
Conductin
axis inhibition protein 2

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88566

RGS domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88566

RGS, subdomain 1/3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88566

DIX domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88566

DIX domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Axin beta-catenin binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Axin-1/2, tankyrase-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Regulator of G protein signalling

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

1 reference

14 February 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

GTPase activator activity

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88566&geneProductId=UniProtKB:O88566

determination method

protein binding

determination method

5 references

14 February 2019

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

14 February 2019

Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-β-catenin signalling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

14 February 2019

Conductin/axin2 and Wnt signalling regulates centrosome cohesion

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

14 February 2019

TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

14 February 2019

Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

ubiquitin protein ligase binding

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

14 February 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

beta-catenin binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

protein kinase binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

determination method

plasma membrane

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88566&geneProductId=UniProtKB:O88566

determination method

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

14 February 2019

RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

determination method

4 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88566&geneProductId=UniProtKB:O88566

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88566&geneProductId=UniProtKB:O88566

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88566&geneProductId=UniProtKB:O88566

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88566&geneProductId=UniProtKB:O88566

determination method

protein-containing complex

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

determination method

3 references

biological process

determination method

1 reference

14 February 2019

Wnt3a plays a major role in the segmentation clock controlling somitogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

intramembranous ossification

determination method

1 reference

14 February 2019

The role of Axin2 in calvarial morphogenesis and craniosynostosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

bone mineralization

determination method

1 reference

14 February 2019

Axin2 regulates chondrocyte maturation and axial skeletal development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

regulation of centromeric sister chromatid cohesion

determination method

Wnt signaling pathway

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

negative regulation of osteoblast differentiation

determination method

1 reference

14 February 2019

The role of Axin2 in calvarial morphogenesis and craniosynostosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

regulation of Wnt signaling pathway

determination method

1 reference

14 February 2019

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

chondrocyte differentiation involved in endochondral bone morphogenesis

determination method

1 reference

14 February 2019

Axin2 regulates chondrocyte maturation and axial skeletal development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

regulation of chondrocyte development

determination method

1 reference

14 February 2019

Axin2 regulates chondrocyte maturation and axial skeletal development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

secondary heart field specification

determination method

1 reference

14 February 2019

Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

cell population proliferation

determination method

1 reference

14 February 2019

Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

negative regulation of cell population proliferation

determination method

positive regulation of GTPase activity

determination method

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88566&geneProductId=UniProtKB:O88566

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

positive regulation of protein kinase activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88566

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000051331

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000051331

ENSMUSP00000102322

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000102322

ENSMUSP00000116956

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000116956

ENSMUSP00000119915

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000119915

ENSMUSP00000120664

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000120664

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