(Q21980211)

English

T-box 3

mammalian protein found in Mus musculus

T-box transcription factor TBX3
Tbx3
T-box protein 3

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

p53-like transcription factor, DNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70324

Transcription factor, T-box

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70324

T-box superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70324

Transcription factor, T-box, region of unknown function, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transcription factor, T-box, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

sequence-specific DNA binding

determination method

3 references

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method

4 references

11 October 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70324&geneProductId=UniProtKB:P70324

determination method

11 October 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70324&geneProductId=UniProtKB:P70324

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

determination method

8 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

T-box 3 is expressed in the adult mouse hypothalamus and medulla

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Expression of Tbx2 and Tbx3 in the developing hypothalamic-pituitary axis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Tbx3 is required for outflow tract development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

biological process

skeletal system development

determination method

3 references

roof of mouth development

determination method

1 reference

14 February 2019

Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

negative regulation of myoblast differentiation

determination method

3 references

male genitalia development

determination method

3 references

regulation of transcription, DNA-templated

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

limb morphogenesis

determination method

1 reference

14 February 2019

Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

branching involved in mammary gland duct morphogenesis

determination method

1 reference

14 February 2019

Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

ventricular septum morphogenesis

determination method

1 reference

14 February 2019

Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

limbic system development

determination method

1 reference

14 February 2019

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

cardiac muscle cell differentiation

determination method

1 reference

14 February 2019

Molecular pathway for the localized formation of the sinoatrial node

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

mammary placode formation

determination method

embryonic digit morphogenesis

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Mouse TBX3 mutants suggest novel molecular mechanisms for Ulnar-mammary syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

heart morphogenesis

determination method

1 reference

14 February 2019

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

outflow tract morphogenesis

determination method

1 reference

14 February 2019

Tbx3 is required for outflow tract development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

negative regulation of apoptotic process

determination method

3 references

in utero embryonic development

determination method

1 reference

14 February 2019

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70324&geneProductId=UniProtKB:P70324

determination method

embryonic heart tube development

determination method

1 reference

14 February 2019

Mouse TBX3 mutants suggest novel molecular mechanisms for Ulnar-mammary syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

mammary gland development

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

stem cell population maintenance

determination method

1 reference

14 February 2019

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

multicellular organism development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

14 February 2019

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

mesoderm morphogenesis

determination method

3 references

sinoatrial node cell development

determination method

1 reference

14 February 2019

Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

cellular senescence

determination method

3 references

atrioventricular bundle cell differentiation

determination method

1 reference

14 February 2019

Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

blood vessel development

determination method

1 reference

14 February 2019

Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

positive regulation of cell cycle

determination method

3 references

regulation of cell population proliferation

determination method

1 reference

14 February 2019

Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodeling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

positive regulation of cell population proliferation

determination method

3 references

cardiac muscle cell fate commitment

determination method

1 reference

14 February 2019

Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

luteinizing hormone secretion

determination method

3 references

negative regulation of transcription, DNA-templated

determination method

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

14 February 2019

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

negative regulation of epithelial cell differentiation

determination method

1 reference

14 February 2019

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

positive regulation of stem cell proliferation

determination method

1 reference

14 February 2019

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

female genitalia development

determination method

3 references

anterior/posterior axis specification, embryo

determination method

3 references

embryonic forelimb morphogenesis

determination method

3 references

specification of animal organ position

determination method

1 reference

14 February 2019

Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

follicle-stimulating hormone secretion

determination method

3 references

embryonic hindlimb morphogenesis

determination method

1 reference

14 February 2019

Mouse TBX3 mutants suggest novel molecular mechanisms for Ulnar-mammary syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70324

determination method

Transcription factor, T-box, region of unknown function

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70324

Transcription factor, T-box, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70324

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000018748

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000018748

ENSMUSP00000078657

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000078657

ENSMUSP00000112519

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000112519

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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