(Q21981175)

http://www.ebi.ac.uk/interpro/protein/Q9EQ21

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

8.A.37.1.1

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

1 reference

25 May 2022

1 reference

25 May 2022

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

1 reference

14 February 2019

A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

3 references

14 February 2019

A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

cellular response to extracellular stimulus

IBA

biological process

1 reference

14 February 2019

Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus

TAS

myeloid cell homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

9 references

14 February 2019

Role of hepcidin in the setting of hypoferremia during acute inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Deletion of HIF-2α in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Characterization of the transition-metal-binding properties of hepcidin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

receptor signaling pathway via JAK-STAT

IDA

1 reference

14 February 2019

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

positive regulation of macrophage activation

IDA

1 reference

14 February 2019

Hepcidin destabilizes atherosclerotic plaque via overactivating macrophages after erythrophagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

negative regulation of transcription by RNA polymerase II

IMP

1 reference

14 February 2019

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

negative regulation of inflammatory response

IMP

1 reference

14 February 2019

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

defense response to fungus

IGI

1 reference

14 February 2019

Structure and exon to protein domain relationships of the mouse carbonic anhydrase II gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

positive regulation of transcription by RNA polymerase II

IDA

1 reference

14 February 2019

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

negative regulation of bone resorption

IGI

1 reference

14 February 2019

Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

negative regulation of iron ion transmembrane transport

IMP

1 reference

24 April 2018

Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9EQ21&geneProductId=UniProtKB:Q9EQ21

regulation of signaling receptor activity

IGI

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

cellular iron ion homeostasis

IEA

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

defense response to bacterium

IBA

3 references

14 February 2019

Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQ21