(Q21981293)

http://www.ebi.ac.uk/interpro/protein/P47941

SH2 domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47941

SH2 domain, protein family

1 reference

CRK, N-terminal SH3 domain, protein family

1 reference

CRK, C-terminal SH3 domain, protein family

1 reference

SH3 domain, protein family

1 reference

Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons

1 reference

31 January 2018

1 reference

31 January 2018

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

14 February 2019

Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

14 February 2019

Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

14 February 2019

Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

14 February 2019

Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47941&geneProductId=UniProtKB:P47941

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

3 references

protein-containing complex

1 reference

14 February 2019

Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

1 reference

14 February 2019

Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

extrinsic component of postsynaptic membrane

1 reference

14 February 2019

Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

pattern specification process

biological process

1 reference

14 February 2019

Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

animal organ morphogenesis

1 reference

14 February 2019

Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

1 reference

14 February 2019

Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome

blood vessel development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

parathyroid gland development

1 reference

14 February 2019

Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

anterior/posterior pattern specification

1 reference

14 February 2019

Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

1 reference

14 February 2019

Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

negative regulation of protein phosphorylation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47941&geneProductId=UniProtKB:P47941

positive regulation of protein phosphorylation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47941&geneProductId=UniProtKB:P47941

negative regulation of gene expression

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47941&geneProductId=UniProtKB:P47941

positive regulation of ERK1 and ERK2 cascade

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47941&geneProductId=UniProtKB:P47941

cellular response to transforming growth factor beta stimulus

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47941&geneProductId=UniProtKB:P47941

positive regulation of glial cell migration

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47941&geneProductId=UniProtKB:P47941

regulation of cell growth

1 reference

14 February 2019

Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

urogenital system development

1 reference

14 February 2019

Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

B cell apoptotic process

1 reference

14 February 2019

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

regulation of leukocyte migration

1 reference

14 February 2019

CRK proteins selectively regulate T cell migration into inflamed tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

outflow tract morphogenesis

1 reference

14 February 2019

Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

1 reference

14 February 2019

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

1 reference

14 February 2019

Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

1 reference

14 February 2019

Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

fibroblast growth factor receptor signaling pathway

1 reference

14 February 2019

Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development

male gonad development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

1 reference

14 February 2019

Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway

hippocampus development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

cerebral cortex development

1 reference

14 February 2019

Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

establishment of cell polarity

1 reference

14 February 2019

CRK proteins selectively regulate T cell migration into inflamed tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

regulation of cell adhesion mediated by integrin

1 reference

14 February 2019

CRK proteins selectively regulate T cell migration into inflamed tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

CRK proteins selectively regulate T cell migration into inflamed tissues

helper T cell diapedesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

reelin-mediated signaling pathway

3 references

14 February 2019

Migration of sympathetic preganglionic neurons in the spinal cord is regulated by Reelin-dependent Dab1 tyrosine phosphorylation and CrkL.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

14 February 2019

Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

14 February 2019

Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

retinoic acid receptor signaling pathway

1 reference

14 February 2019

A mouse splice-site mutant and individuals with atypical chromosome 22q11.2 deletions demonstrate the crucial role for crkl in craniofacial and pharyngeal development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

regulation of dendrite development

1 reference

14 February 2019

Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

T cell receptor signaling pathway

1 reference

14 February 2019

The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

1 reference

14 February 2019

CRK proteins selectively regulate T cell migration into inflamed tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

1 reference

14 February 2019

A mouse splice-site mutant and individuals with atypical chromosome 22q11.2 deletions demonstrate the crucial role for crkl in craniofacial and pharyngeal development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

positive regulation of ERK1 and ERK2 cascade

3 references

endothelin receptor signaling pathway

1 reference

14 February 2019

A mouse splice-site mutant and individuals with atypical chromosome 22q11.2 deletions demonstrate the crucial role for crkl in craniofacial and pharyngeal development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

activation of GTPase activity

1 reference

14 February 2019

CRK proteins selectively regulate T cell migration into inflamed tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

acetylcholine receptor signaling pathway

1 reference

14 February 2019

Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

cerebellar neuron development

1 reference

14 February 2019

Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

cellular response to interleukin-7

1 reference

14 February 2019

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

regulation of skeletal muscle acetylcholine-gated channel clustering

1 reference

14 February 2019

Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

cranial skeletal system development

1 reference

14 February 2019

A mouse splice-site mutant and individuals with atypical chromosome 22q11.2 deletions demonstrate the crucial role for crkl in craniofacial and pharyngeal development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941

regulation of T cell migration

1 reference

14 February 2019

CRK proteins selectively regulate T cell migration into inflamed tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47941