(Q21981401)

http://www.ebi.ac.uk/interpro/protein/Q6SJE0

glial cell line-derived neurotrophic factor receptor

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6SJE0

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

GDNF/GAS1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

signaling receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

glial cell-derived neurotrophic factor receptor activity

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6SJE0&geneProductId=UniProtKB:Q6SJE0

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6SJE0&geneProductId=UniProtKB:Q6SJE0

5 June 2018

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6SJE0&geneProductId=UniProtKB:Q6SJE0

5 June 2018

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6SJE0&geneProductId=UniProtKB:Q6SJE0

5 June 2018

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6SJE0&geneProductId=UniProtKB:Q6SJE0

glial cell-derived neurotrophic factor receptor activity

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

receptor tyrosine kinase binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

integral component of membrane

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

1 reference

24 April 2018

Identification, expression and functional characterization of the GRAL gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6SJE0&geneProductId=UniProtKB:Q6SJE0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

intracellular anatomical structure

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6SJE0&geneProductId=UniProtKB:Q6SJE0

external side of plasma membrane

external side of plasma membrane

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

negative regulation of neuron apoptotic process

IBA

biological process

1 reference

14 February 2019

Identification, expression and functional characterization of the GRAL gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

stress-activated protein kinase signaling cascade

1 reference

14 February 2019

Identification, expression and functional characterization of the GRAL gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

1 reference

14 February 2019

Identification, expression and functional characterization of the GRAL gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

reduction of food intake in response to dietary excess

4 references

14 February 2019

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

14 February 2019

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

positive regulation of MAPK cascade

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6SJE0&geneProductId=UniProtKB:Q6SJE0

glial cell-derived neurotrophic factor receptor signaling pathway

3 references

positive regulation of protein kinase B signaling

3 references

nervous system development

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6SJE0

1 reference

InterPro Release 71.0