(Q21981429)

English

Reticulon 4

mammalian protein found in Mus musculus

Rtn4
neurite outgrowth inhibitor
reticulon-4
Nogo protein

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Reticulon domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method

6 references

14 February 2019

Endoplasmic Protein Nogo-B (RTN4-B) Interacts with GRAMD4 and Regulates TLR9-Mediated Innate Immune Responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Nogo-A couples with Apg-1 through interaction and co-ordinate expression under hypoxic and oxidative stress

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

protein-containing complex binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

cadherin binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

protein homodimerization activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

integral component of membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

cell projection

determination method

1 reference

14 February 2019

Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

nuclear envelope

determination method

3 references

14 February 2019

A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

integral component of endoplasmic reticulum membrane

determination method

3 references

14 February 2019

Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

endoplasmic reticulum

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Expression of Nogo protein by growing axons in the developing nervous system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

endoplasmic reticulum membrane

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

postsynaptic density

determination method

1 reference

14 February 2019

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

endoplasmic reticulum tubular network membrane

determination method

3 references

determination method

1 reference

24 April 2018

Isoform-specific localization of Nogo protein in the optic pathway of mouse embryos.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99P72&geneProductId=UniProtKB:Q99P72

determination method

dendritic growth cone

determination method

1 reference

24 April 2018

Isoform-specific localization of Nogo protein in the optic pathway of mouse embryos.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99P72&geneProductId=UniProtKB:Q99P72

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

plasma membrane

determination method

1 reference

14 January 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99P72&geneProductId=UniProtKB:Q99P72

determination method

protein-containing complex

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

neuron projection

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

glutamatergic synapse

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

integral component of postsynaptic density membrane

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

plasma membrane

determination method

2 references

determination method

2 references

biological process

cerebral cortex radial glia-guided migration

determination method

1 reference

14 February 2019

Nogo-a regulates neural precursor migration in the embryonic mouse cortex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

cardiac epithelial to mesenchymal transition

determination method

1 reference

14 February 2019

Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

regulation of nervous system development

determination method

1 reference

14 February 2019

Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

endoplasmic reticulum tubular network organization

determination method

3 references

negative regulation of axon extension

determination method

4 references

14 February 2019

Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

nuclear pore complex assembly

determination method

3 references

regulation of cell migration

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

endoplasmic reticulum tubular network formation

determination method

3 references

protein stabilization

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

endoplasmic reticulum tubular network membrane organization

determination method

3 references

determination method

1 reference

24 April 2018

A new role for Nogo as a regulator of vascular remodeling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99P72&geneProductId=UniProtKB:Q99P72

determination method

positive regulation of collateral sprouting of injured axon

determination method

1 reference

24 April 2018

Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99P72&geneProductId=UniProtKB:Q99P72

determination method

negative regulation of dendrite extension

determination method

1 reference

24 April 2018

Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99P72&geneProductId=UniProtKB:Q99P72

determination method

negative regulation of formation of growth cone in injured axon

determination method

1 reference

24 April 2018

Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99P72&geneProductId=UniProtKB:Q99P72

determination method

negative regulation of neuron projection development

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

positive regulation of dopamine secretion

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

negative regulation of neuron differentiation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

positive regulation of glial cell differentiation

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

negative regulation of axonogenesis

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

regulation of sensory perception of pain

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

negative regulation of neuron projection regeneration

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

axonal fasciculation

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

blastocyst formation

determination method

1 reference

14 February 2019

Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

positive regulation of toll-like receptor 9 signaling pathway

determination method

1 reference

14 February 2019

Endoplasmic Protein Nogo-B (RTN4-B) Interacts with GRAMD4 and Regulates TLR9-Mediated Innate Immune Responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

protein localization to lysosome

determination method

1 reference

14 February 2019

Endoplasmic Protein Nogo-B (RTN4-B) Interacts with GRAMD4 and Regulates TLR9-Mediated Innate Immune Responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

cellular sphingolipid homeostasis

determination method

1 reference

14 February 2019

Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

endoplasmic reticulum organization

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

cell adhesion involved in sprouting angiogenesis

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P72

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99P72

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000053754

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000053754

ENSMUSP00000099905

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000099905

ENSMUSP00000099907

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000099907

ENSMUSP00000077875

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000077875

ENSMUSP00000099906

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000099906

ENSMUSP00000126413

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000126413

PDB structure ID

1 reference

UniProt protein ID

10 August 2016

language of work or name

Sitelinks

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