(Q21981437)

serine-type endopeptidase activity

ISO

3 references

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

3 references

14 February 2019

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

integral component of membrane

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

3 references

mitochondrial membranes

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

mitochondrial intermembrane space

3 references

14 February 2019

Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

6 references

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JIY5&geneProductId=UniProtKB:Q9JIY5

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JIY5&geneProductId=UniProtKB:Q9JIY5

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JIY5&geneProductId=UniProtKB:Q9JIY5

10 October 2017

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JIY5&geneProductId=UniProtKB:Q9JIY5

10 October 2017

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JIY5&geneProductId=UniProtKB:Q9JIY5

10 October 2017

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JIY5&geneProductId=UniProtKB:Q9JIY5

HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex

IDA

CD40 receptor complex

1 reference

14 February 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

cytoplasmic side of plasma membrane

IDA

1 reference

14 February 2019

HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

ceramide metabolic process

HDA

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

adult locomotory behavior

1 reference

14 February 2019

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

pentacyclic triterpenoid metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

mitochondrion organization

1 reference

14 February 2019

Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

1 reference

14 February 2019

mnd2: a new mouse model of inherited motor neuron disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

intrinsic apoptotic signaling pathway

1 reference

14 February 2019

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

positive regulation of apoptotic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

forebrain development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

response to herbicide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

mnd2: a new mouse model of inherited motor neuron disease

adult walking behavior

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

negative regulation of cell death

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JIY5&geneProductId=UniProtKB:Q9JIY5

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

cellular response to oxidative stress

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

negative regulation of mitophagy in response to mitochondrial depolarization

1 reference

14 February 2019

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIY5

1 reference

InterPro Release 71.0