(Q21981698)

English

Cullin 4A

mammalian protein found in Mus musculus

cullin-4A
Cul4a
CUL-4A

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q3TCH7

Cullin homology domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q3TCH7

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q3TCH7

Cullin repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q3TCH7

Cullin, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cullin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cullin protein, neddylation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cullin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

ubiquitin protein ligase activity

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

cullin-RING ubiquitin ligase complex

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3TCH7&geneProductId=UniProtKB:Q3TCH7

determination method

Cul4-RING E3 ubiquitin ligase complex

determination method

Cul4A-RING E3 ubiquitin ligase complex

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

Cul4-RING E3 ubiquitin ligase complex

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

SCF ubiquitin ligase complex

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

biological process

positive regulation of protein catabolic process

determination method

1 reference

14 February 2019

A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

negative regulation of granulocyte differentiation

determination method

1 reference

14 February 2019

Enforced expression of CUL-4A interferes with granulocytic differentiation and exit from the cell cycle

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

somatic stem cell population maintenance

determination method

1 reference

14 February 2019

Cul4A is required for hematopoietic stem-cell engraftment and self-renewal

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

in utero embryonic development

determination method

1 reference

14 February 2019

CUL-4A is critical for early embryonic development

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

positive regulation of G1/S transition of mitotic cell cycle

determination method

1 reference

14 February 2019

A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

regulation of nucleotide-excision repair

determination method

1 reference

14 February 2019

CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

regulation of DNA damage checkpoint

determination method

1 reference

14 February 2019

CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

positive regulation of cell population proliferation

determination method

1 reference

14 February 2019

Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

regulation of protein metabolic process

determination method

1 reference

14 February 2019

A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

cellular response to DNA damage stimulus

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3TCH7&geneProductId=UniProtKB:Q3TCH7

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

3 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3TCH7&geneProductId=UniProtKB:Q3TCH7

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3TCH7&geneProductId=UniProtKB:Q3TCH7

determination method

10 September 2018

Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3TCH7&geneProductId=UniProtKB:Q3TCH7

determination method

protein ubiquitination

determination method

3 references

determination method

1 reference

14 February 2019

Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

ubiquitin-dependent protein catabolic process

determination method

3 references

14 February 2019

CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

14 February 2019

Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3TCH7

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000016680

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000016680

ENSMUSP00000112525

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000112525

ENSMUSP00000123074

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000123074

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Multilingual sites(0 entries)

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