(Q21981875)

http://www.ebi.ac.uk/interpro/protein/P97767

EYA domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97767

EYA domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

phosphoprotein phosphatase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

4 references

14 February 2019

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

1 reference

14 February 2019

The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

protein tyrosine phosphatase activity

5 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

27 February 2018

Eyes absent represents a class of protein tyrosine phosphatases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

protein tyrosine phosphatase activity

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

Eyes absent represents a class of protein tyrosine phosphatases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

1 reference

14 February 2019

A Hox-Eya-Pax complex regulates early kidney developmental gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

5 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

27 February 2018

Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

protein-containing complex

1 reference

14 February 2019

A Hox-Eya-Pax complex regulates early kidney developmental gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

response to ionizing radiation

IBA

biological process

3 references

regulation of neuron differentiation

embryonic skeletal system morphogenesis

1 reference

14 February 2019

Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme

ureteric bud development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

striated muscle tissue development

1 reference

14 February 2019

Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

semicircular canal morphogenesis

1 reference

14 February 2019

Inner ear and kidney anomalies caused by IAP insertion in an intron of the Eya1 gene in a mouse model of BOR syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

regulation of transcription, DNA-templated

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

anatomical structure development

1 reference

27 February 2018

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

positive regulation of epithelial cell proliferation

1 reference

14 February 2019

Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

neuron fate specification

1 reference

14 February 2019

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

protein dephosphorylation

1 reference

14 February 2019

Eyes absent represents a class of protein tyrosine phosphatases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

outflow tract morphogenesis

1 reference

14 February 2019

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

otic vesicle morphogenesis

1 reference

14 February 2019

Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia

outer ear morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

1 reference

14 February 2019

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

1 reference

14 February 2019

SUMO1 haploinsufficiency leads to cleft lip and palate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

transcription, DNA-templated

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear

otic vesicle development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

cellular response to DNA damage stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

multicellular organism development

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

positive regulation of transcription, DNA-templated

1 reference

14 February 2019

A Hox-Eya-Pax complex regulates early kidney developmental gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

branching involved in ureteric bud morphogenesis

1 reference

14 February 2019

Six1 is required for the early organogenesis of mammalian kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

double-strand break repair

3 references

inner ear morphogenesis

3 references

14 February 2019

Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

Inner ear and kidney anomalies caused by IAP insertion in an intron of the Eya1 gene in a mouse model of BOR syndrome

cochlea morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia

middle ear morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

positive regulation of secondary heart field cardioblast proliferation

1 reference

14 February 2019

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

peptidyl-tyrosine dephosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

1 reference

27 February 2018

Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97767&geneProductId=UniProtKB:P97767

mesodermal cell fate specification

1 reference

14 February 2019

A Hox-Eya-Pax complex regulates early kidney developmental gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

positive regulation of transcription by RNA polymerase II

pharyngeal system development

1 reference

14 February 2019

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

positive regulation of DNA repair

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97767

IBA

chromatin organization

1 reference

14 February 2019

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

1 reference

InterPro Release 71.0