(Q21982339)

http://www.ebi.ac.uk/interpro/protein/P30681

High mobility group box domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HMG box A DNA-binding domain, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein domain specific binding

1 reference

14 February 2019

High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

IPI

supercoiled DNA binding

1 reference

14 February 2019

non-sequence-specific DNA binding, bending

ISS

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

cis-regulatory region sequence-specific DNA binding

ISS

1 reference

14 February 2019

Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

transcription factor binding

1 reference

27 March 2018

Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

1 reference

14 February 2019

Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

DNA-binding transcription factor activity

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

transcription coactivator activity

ISO

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

27 March 2018

A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

perinuclear region of cytoplasm

3 references

3 references

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

response to steroid hormone

biological process

1 reference

14 February 2019

Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

regulation of stem cell proliferation

1 reference

14 February 2019

Aberrant neural stem cell proliferation and increased adult neurogenesis in mice lacking chromatin protein HMGB2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

response to lipopolysaccharide

1 reference

14 February 2019

A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

negative regulation of gene expression

1 reference

14 February 2019

Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

cellular response to lipopolysaccharide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

positive regulation of gene expression

1 reference

14 February 2019

Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

inflammatory response to antigenic stimulus

1 reference

14 February 2019

A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

regulation of neurogenesis

1 reference

14 February 2019

Aberrant neural stem cell proliferation and increased adult neurogenesis in mice lacking chromatin protein HMGB2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

innate immune response

1 reference

14 February 2019

regulation of transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

spermatid nucleus differentiation

1 reference

14 February 2019

Changes in intranuclear chromatin architecture induce bipolar nuclear localization of histone variant H1T2 in male haploid spermatids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

positive regulation of interferon-beta production

1 reference

14 February 2019

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

immune system process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

inflammatory response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

DNA topological change

1 reference

14 February 2019

Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2

ISS

male gonad development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

positive regulation of innate immune response

1 reference

27 March 2018

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

regulation of transcription by RNA polymerase II

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

27 March 2018

High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

defense response to Gram-negative bacterium

3 references

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

positive regulation of DNA binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

positive regulation of transcription by RNA polymerase II

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

27 March 2018

Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30681&geneProductId=UniProtKB:P30681

defense response to Gram-positive bacterium

3 references

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

1 reference

14 February 2019

Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

regulation of transcription by RNA polymerase II

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

positive regulation of transcription by RNA polymerase II

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30681

HMG box A DNA-binding domain, conserved site

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30681

High mobility group box domain

1 reference

stated in

InterPro Release 71.0