(Q21983822)

DHS-like NAD/FAD-binding domain superfamily

1 reference

stated in

Sirtuin, catalytic core small domain superfamily

1 reference

stated in

Sirtuin family, catalytic core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein-succinyllysine desuccinylase activity

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

protein-malonyllysine demalonylase activity

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

1 reference

14 February 2019

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

3 references

protein-glutaryllysine deglutarylase activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

8 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

1 January 2018

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

1 January 2018

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

1 January 2018

Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

1 January 2018

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

mitochondrial inner membrane

1 reference

14 February 2019

Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

mitochondrial intermembrane space

3 references

3 references

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

HDA

biological process

protein deacetylation

1 reference

14 February 2019

regulation of ketone biosynthetic process

ISS

1 reference

14 February 2019

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

peptidyl-lysine deglutarylation

IMP

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

negative regulation of cardiac muscle cell apoptotic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

response to nutrient levels

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

protein demalonylation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

peptidyl-lysine demalonylation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

protein desuccinylation

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

peptidyl-lysine desuccinylation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

protein deglutarylation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

14 February 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

Sirtuin family, catalytic core domain

has part(s)

1 reference

stated in