(Q21984076)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35428

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Orange domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

1 reference

9 May 2019

DNA-binding transcription factor activity

ISS

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

9 May 2019

Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

protein binding

3 references

9 May 2019

HeyL promotes neuronal differentiation of neural progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

chaperone binding

1 reference

9 May 2019

Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

DNA binding

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

9 May 2019

The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

chromatin binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

transcription factor binding

NAS

JUN kinase binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

protein-containing complex binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

E-box binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

DNA-binding transcription repressor activity, RNA polymerase II-specific

HeyL promotes neuronal differentiation of neural progenitor cells

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

9 May 2019

HeyL promotes neuronal differentiation of neural progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

transcription corepressor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

transcription factor binding

Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

sequence-specific DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

N-box binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

sequence-specific double-stranded DNA binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

cell component

cytoplasm

1 reference

9 May 2019

Gene expression profile analysis of mouse colon embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

intracellular anatomical structure

1 reference

10 September 2018

Patched1 functions as a gatekeeper by promoting cell cycle progression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

nucleus

9 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

24 April 2018

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

24 April 2018

Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

24 April 2018

Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

24 April 2018

Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

24 April 2018

Canonical notch signaling functions as a commitment switch in the epidermal lineage

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

24 April 2018

Gene expression profile analysis of mouse colon embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

1 reference

9 May 2019

chromatin

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

nuclear matrix

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

nucleus

10 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Canonical notch signaling functions as a commitment switch in the epidermal lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Gene expression profile analysis of mouse colon embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

auditory receptor cell fate determination

biological process

1 reference

14 February 2019

Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

midbrain-hindbrain boundary morphogenesis

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of neuron differentiation

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Multiple requirements for Hes 1 during early eye formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

inner ear receptor cell stereocilium organization

1 reference

9 May 2019

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

metanephric nephron tubule morphogenesis

1 reference

9 May 2019

Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

cell morphogenesis involved in neuron differentiation

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of glial cell proliferation

1 reference

9 May 2019

Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

outflow tract morphogenesis

lateral inhibition

1 reference

9 May 2019

Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

cardiac neural crest cell development involved in outflow tract morphogenesis

1 reference

9 May 2019

Hes1 is expressed in the second heart field and is required for outflow tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

inner ear auditory receptor cell differentiation

1 reference

14 February 2019

Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of pro-B cell differentiation

ISS

positive regulation of DNA binding

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

vascular associated smooth muscle cell development

1 reference

9 May 2019

Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of inner ear receptor cell differentiation

1 reference

9 May 2019

Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

regulation of neurogenesis

positive regulation of Notch signaling pathway

1 reference

9 May 2019

Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

endocrine pancreas development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

1 reference

9 May 2019

cell fate commitment

1 reference

9 May 2019

Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

1 reference

9 May 2019

ventricular septum development

1 reference

9 May 2019

Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

lung development

1 reference

9 May 2019

Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of inner ear auditory receptor cell differentiation

1 reference

14 February 2019

Hes1 is a negative regulator of inner ear hair cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

thymus development

1 reference

9 May 2019

Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of cell differentiation

ventricular septum morphogenesis

1 reference

9 May 2019

Hes1 is expressed in the second heart field and is required for outflow tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

labyrinthine layer blood vessel development

1 reference

9 May 2019

Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

in utero embryonic development

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

cell maturation

1 reference

9 May 2019

Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

adenohypophysis development

1 reference

9 May 2019

Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

regulation of timing of neuron differentiation

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects

2 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

1 reference

24 April 2018

regulation of fat cell differentiation

1 reference

9 May 2019

Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

positive regulation of transcription, DNA-templated

1 reference

9 May 2019

Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

telencephalon development

pharyngeal arch artery morphogenesis

1 reference

9 May 2019

Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

positive regulation of T cell proliferation

1 reference

9 May 2019

Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

artery morphogenesis

1 reference

9 May 2019

Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

pancreas development

1 reference

9 May 2019

Sox17 regulates organ lineage segregation of ventral foregut progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

hindbrain morphogenesis

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

smoothened signaling pathway

1 reference

9 May 2019

Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of stomach neuroendocrine cell differentiation

1 reference

9 May 2019

Mash1 is required for neuroendocrine cell development in the glandular stomach

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

Notch signaling pathway

Segmental expression of Notch and Hairy genes in nephrogenesis

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

24 April 2018

Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

24 April 2018

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

ureteric bud morphogenesis

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

regulation of inner ear auditory receptor cell differentiation

1 reference

14 February 2019

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

oculomotor nerve development

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

regulation of timing of cell differentiation

2 references

9 May 2019

Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

positive regulation of astrocyte differentiation

1 reference

9 May 2019

Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

ascending aorta morphogenesis

1 reference

9 May 2019

Hes1 is expressed in the second heart field and is required for outflow tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of transcription by RNA polymerase II

10 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Hes1 is expressed in the second heart field and is required for outflow tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

HeyL promotes neuronal differentiation of neural progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

14 February 2019

Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

cell adhesion

1 reference

9 May 2019

Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

positive regulation of BMP signaling pathway

1 reference

9 May 2019

Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of transcription, DNA-templated

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

positive regulation of receptor signaling pathway via JAK-STAT

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

midbrain development

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

establishment of epithelial cell polarity

1 reference

9 May 2019

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

pituitary gland development

Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

comma-shaped body morphogenesis

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

somatic stem cell population maintenance

1 reference

9 May 2019

Control of endodermal endocrine development by Hes-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

trochlear nerve development

1 reference

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

aorta morphogenesis

1 reference

9 May 2019

Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of pancreatic A cell differentiation

1 reference

9 May 2019

Control of endodermal endocrine development by Hes-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

regulation of secondary heart field cardioblast proliferation

1 reference

9 May 2019

Hes1 is expressed in the second heart field and is required for outflow tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

common bile duct development

1 reference

9 May 2019

Sox17 regulates organ lineage segregation of ventral foregut progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

renal interstitial fibroblast development

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

S-shaped body morphogenesis

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

embryonic heart tube morphogenesis

1 reference

9 May 2019

Hes1 is expressed in the second heart field and is required for outflow tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

glomerulus vasculature development

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

positive regulation of cell population proliferation

3 references

9 May 2019

Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Multiple requirements for Hes 1 during early eye formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

positive regulation of mitotic cell cycle, embryonic

1 reference

9 May 2019

Hes1 is expressed in the second heart field and is required for outflow tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

liver development

1 reference

9 May 2019

The role of notch signaling in the development of intrahepatic bile ducts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

regulation of epithelial cell proliferation

1 reference

9 May 2019

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

cell migration

1 reference

9 May 2019

Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

positive regulation of transcription by RNA polymerase II

Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 is expressed in the second heart field and is required for outflow tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

protein-containing complex assembly

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

regulation of receptor signaling pathway via JAK-STAT

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

positive regulation of gene expression

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of gene expression

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of neuron projection development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

hair cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

regulation of protein heterodimerization activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

positive regulation of glial cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of neurogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of calcium ion import

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

neuronal stem cell population maintenance

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35428&geneProductId=UniProtKB:P35428

cellular response to nerve growth factor stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

somitogenesis

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

Notch signaling pathway

Segmental expression of Notch and Hairy genes in nephrogenesis

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

cell differentiation

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

regulation of neurogenesis

Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of transcription by RNA polymerase II

11 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 is expressed in the second heart field and is required for outflow tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

HeyL promotes neuronal differentiation of neural progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

anterior/posterior pattern specification

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of inner ear auditory receptor cell differentiation

Hes1 is a negative regulator of inner ear hair cell differentiation

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of neuron differentiation

Multiple requirements for Hes 1 during early eye formation

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

negative regulation of cell fate determination

1 reference

9 May 2019

Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35428

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35428

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

InterPro Release 71.0