(Q21984077)

http://www.ebi.ac.uk/interpro/protein/P70120

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Orange domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein dimerization activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

transcription factor binding

1 reference

9 May 2019

Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

RNA polymerase II transcription regulatory region sequence-specific DNA binding

NAS

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

DNA-binding transcription repressor activity, RNA polymerase II-specific

4 references

10 September 2018

HeyL promotes neuronal differentiation of neural progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70120&geneProductId=UniProtKB:P70120

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70120&geneProductId=UniProtKB:P70120

9 May 2019

HeyL promotes neuronal differentiation of neural progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

transcription corepressor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

transcription factor binding

sequence-specific DNA binding

NAS

2 references

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

sequence-specific double-stranded DNA binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70120&geneProductId=UniProtKB:P70120

Segmental expression of Notch and Hairy genes in nephrogenesis

biological process

Notch signaling pathway

6 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70120&geneProductId=UniProtKB:P70120

24 April 2018

Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70120&geneProductId=UniProtKB:P70120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70120&geneProductId=UniProtKB:P70120

24 April 2018

Identification of self-replicating multipotent progenitors in the embryonic nervous system by high Notch activity and Hes5 expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70120&geneProductId=UniProtKB:P70120

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70120&geneProductId=UniProtKB:P70120

24 April 2018

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70120&geneProductId=UniProtKB:P70120

auditory receptor cell fate determination

1 reference

14 February 2019

Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

establishment of epithelial cell polarity

1 reference

9 May 2019

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70120&geneProductId=UniProtKB:P70120

negative regulation of astrocyte differentiation

1 reference

9 May 2019

Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

regulation of inner ear auditory receptor cell differentiation

1 reference

14 February 2019

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

negative regulation of neuron differentiation

4 references

14 February 2019

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

14 February 2019

Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

14 February 2019

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

14 February 2019

Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

chondrocyte differentiation

1 reference

9 May 2019

Notch and HES5 are regulated during human cartilage differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

inner ear receptor cell stereocilium organization

1 reference

9 May 2019

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

comma-shaped body morphogenesis

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

metanephric nephron tubule morphogenesis

1 reference

9 May 2019

Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

central nervous system myelination

1 reference

9 May 2019

A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

negative regulation of transcription by RNA polymerase II

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

14 February 2019

A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

14 February 2019

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

1 reference

9 May 2019

Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70120&geneProductId=UniProtKB:P70120

nervous system development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

negative regulation of stem cell differentiation

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

positive regulation of transcription, DNA-templated

1 reference

9 May 2019

Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

glial cell fate commitment

1 reference

9 May 2019

Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

1 reference

9 May 2019

Identification of self-replicating multipotent progenitors in the embryonic nervous system by high Notch activity and Hes5 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

inner ear auditory receptor cell differentiation

1 reference

14 February 2019

Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

1 reference

9 May 2019

Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

astrocyte differentiation

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

regulation of myelination

cartilage development

1 reference

9 May 2019

A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

negative regulation of oligodendrocyte differentiation

S-shaped body morphogenesis

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium

neural tube development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

neuron differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

positive regulation of cell population proliferation

positive regulation of BMP signaling pathway

1 reference

9 May 2019

Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

regulation of cell differentiation

1 reference

9 May 2019

Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

smoothened signaling pathway

1 reference

9 May 2019

Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

oligodendrocyte development

1 reference

9 May 2019

A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

camera-type eye development

1 reference

9 May 2019

Identification of self-replicating multipotent progenitors in the embryonic nervous system by high Notch activity and Hes5 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

specification of loop of Henle identity

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

regulation of epithelial cell proliferation

1 reference

9 May 2019

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

negative regulation of inner ear receptor cell differentiation

1 reference

9 May 2019

Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

positive regulation of receptor signaling pathway via JAK-STAT

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

positive regulation of Notch signaling pathway

1 reference

9 May 2019

Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

positive regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

positive regulation of smooth muscle cell proliferation

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

protein-containing complex assembly

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

negative regulation of transcription, DNA-templated

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

neuronal stem cell population maintenance

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

negative regulation of pro-B cell differentiation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

Segmental expression of Notch and Hairy genes in nephrogenesis

Notch signaling pathway

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Identification of self-replicating multipotent progenitors in the embryonic nervous system by high Notch activity and Hes5 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

regulation of neurogenesis

3 references

9 May 2019

Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

negative regulation of transcription by RNA polymerase II

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

central nervous system development

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

anterior/posterior pattern specification

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of neuron differentiation

5 references

9 May 2019

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70120

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70120

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

stated in

InterPro Release 71.0