(Q21984225)

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

protein homodimerization activity

1 reference

14 February 2019

Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

protein serine/threonine kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

1 reference

14 February 2019

Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

2 references

eukaryotic translation initiation factor 2alpha kinase activity

1 reference

14 February 2019

Autophosphorylation of heme-regulated eukaryotic initiation factor 2α kinase and the role of the modification in catalysis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

IPI

protein kinase activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

eukaryotic translation initiation factor 2alpha kinase activity

IBA

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

14 February 2019

Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

14 February 2019

The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

negative regulation of translation

IDA

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

regulation of hemoglobin biosynthetic process

1 reference

14 February 2019

Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

1 reference

14 February 2019

The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

macrophage differentiation

1 reference

14 February 2019

The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

protein phosphorylation

1 reference

14 February 2019

acute inflammatory response

1 reference

14 February 2019

The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

protoporphyrinogen IX metabolic process

1 reference

14 February 2019

Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

regulation of eIF2 alpha phosphorylation by heme

IGI

1 reference

14 February 2019

Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

negative regulation of hemoglobin biosynthetic process

IGI

1 reference

14 February 2019

Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

1 reference

14 February 2019

The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

protein autophosphorylation

1 reference

14 February 2019

Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

regulation of translation

IEP

1 reference

14 February 2019

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

negative regulation of cell population proliferation

1 reference

14 February 2019

Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

regulation of translational initiation by eIF2 alpha phosphorylation

IDA

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2R9

response to iron ion starvation

3 references

serine/threonine-protein kinase, active site

1 reference

protein kinase domain

1 reference

protein kinase, ATP binding site

1 reference