(Q21984700)

membrane proteins

1 reference

inferred from GOA cell component → membrane

Serine/threonine-protein kinase OSR1/WNK, CCT domain, protein family

1 reference

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

4 references

14 February 2019

The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

2 references

protein serine/threonine kinase activity

6 references

24 April 2018

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

24 April 2018

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

protein kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

protein serine/threonine kinase activity

7 references

14 February 2019

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

1 reference

14 February 2019

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

basolateral plasma membrane

1 reference

14 February 2019

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)

apical plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

3 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

negative regulation of protein phosphorylation

biological process

1 reference

24 April 2018

A SPAK isoform switch modulates renal salt transport and blood pressure

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

intracellular signal transduction

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

cellular hypotonic response

1 reference

14 February 2019

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

regulation of blood pressure

IGI

1 reference

14 February 2019

A SPAK isoform switch modulates renal salt transport and blood pressure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

negative regulation of potassium ion transmembrane transporter activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

regulation of inflammatory response

1 reference

14 February 2019

Overexpression of Ste20-related proline/alanine-rich kinase exacerbates experimental colitis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

negative regulation of potassium ion transmembrane transport

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

24 April 2018

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

24 April 2018

Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

negative regulation of pancreatic juice secretion

1 reference

14 February 2019

IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

maintenance of lens transparency

1 reference

14 February 2019

Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

regulation of mitotic cell cycle

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

3 references

stress-activated protein kinase signaling cascade

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

activation of protein kinase activity

IBA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

regulation of apoptotic process

IBA

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

peptidyl-threonine phosphorylation

IBA

4 references

14 February 2019

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

protein autophosphorylation

3 references

24 April 2018

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1W9&geneProductId=UniProtKB:Q9Z1W9

1 reference

14 February 2019

A SPAK isoform switch modulates renal salt transport and blood pressure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

protein phosphorylation

ISO

protein phosphorylation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

protein autophosphorylation

4 references

14 February 2019

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

negative regulation of potassium ion transmembrane transport

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1W9

Serine/threonine-protein kinase OSR1/WNK, CCT domain

has part(s)

1 reference

protein kinase domain

1 reference

protein kinase, ATP binding site

1 reference