(Q21984932)

Ureohydrolase domain superfamily

1 reference

Histone deacetylase, subgroup

1 reference

inferred from protein domain or family

histone deacetylases

1 reference

based on heuristic

1 reference

2 March 2022

1 reference

2 March 2022

NAD-dependent histone deacetylase activity (H3-K14 specific)

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

histone deacetylase activity

4 references

24 April 2018

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

protein deacetylase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

transcription factor binding

3 references

8 April 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

histone deacetylase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

12 references

8 April 2019

Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Adipose is a conserved dosage-sensitive antiobesity gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Chromatin regulation by Brg1 underlies heart muscle development and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation

chromatin DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

histone deacetylase activity

5 references

8 April 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

7 references

8 April 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

histone deacetylase complex

1 reference

24 April 2018

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

7 references

8 April 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

histone deacetylase complex

3 references

8 April 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

biological process

histone H3 deacetylation

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

regulation of transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

regulation of multicellular organism growth

1 reference

8 April 2019

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

negative regulation of transcription by RNA polymerase II

IGI

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

negative regulation of DNA-binding transcription factor activity

IGI

1 reference

8 April 2019

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

circadian regulation of gene expression

1 reference

14 January 2019

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

transcription, DNA-templated

IGI

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

protein deacetylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

negative regulation of JNK cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

negative regulation of cardiac muscle cell differentiation

1 reference

8 April 2019

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

regulation of mitotic cell cycle

IMP

1 reference

8 April 2019

Cloning and expression of a murine histone deacetylase 3 (mHdac3) cDNA and mapping to a region of conserved synteny between murine chromosome 18 and human chromosome 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

negative regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3

histone deacetylation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

JDP2 suppresses adipocyte differentiation by regulating histone acetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

histone H4 deacetylation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88895&geneProductId=UniProtKB:O88895

histone H4-K12 deacetylation

1 reference

8 April 2019

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

negative regulation of interleukin-1 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

negative regulation of tumor necrosis factor production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

positive regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

negative regulation of protein export from nucleus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

positive regulation of type B pancreatic cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

positive regulation of transcription by RNA polymerase II

3 references

histone H3 deacetylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

positive regulation of cold-induced thermogenesis

IBA

1 reference

8 April 2019

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

positive regulation of protein ubiquitination

IMP

1 reference

8 April 2019

Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

regulation of circadian rhythm

IMP

1 reference

8 April 2019

Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88895

Histone deacetylase domain

has part(s)

1 reference