(Q28511624)

25 January 2017

title

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor (English)

1 reference

Transcriptional regulator, SIN3A (yeast)

25 January 2017

0 references

0 references

1 reference

Methyl CpG binding protein 2

1 reference

Histone deacetylase 3

1 reference

Transducin (beta)-like 1 X-linked

1 reference

Nuclear receptor corepressor 1

1 reference

Nuclear receptor co-repressor 2

1 reference

Transducin (beta)-like 1X-linked receptor 1

1 reference

author

Flavia de Lima Alves

10

0 references

Juri Rappsilber

11

0 references

Robert Ekiert

Robert Ekiert

2

0 references

Jim Selfridge

Jim Selfridge

6

0 references

Adrian Peter Bird

Adrian Bird

13

0 references

Jacky Guy

Jacky Guy

7

0 references

author name string

Matthew J. Lyst

1

1 reference

25 January 2017

Daniel H. Ebert

3

1 reference

25 January 2017

Cara Merusi

4

1 reference

25 January 2017

Jakub Nowak

5

1 reference

25 January 2017

Nathaniel R. Kastan

8

1 reference

25 January 2017

Nathaniel D. Robinson

9

1 reference

25 January 2017

Michael E. Greenberg

12

1 reference

25 January 2017

language of work or name

English

0 references

publication date

1 July 2013

1 reference

25 January 2017

1 reference

25 January 2017

volume

16

1 reference

25 January 2017

issue

7

1 reference

25 January 2017

page(s)

898–902

1 reference

MeCP2, a key contributor to neurological disease, activates and represses transcription

25 January 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins

19 March 2017

1 reference

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Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Phenotypic manifestations of MECP2 mutations in classical and atypical Rett syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

The Ski protein family is required for MeCP2-mediated transcriptional repression

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Reversal of neurological defects in a mouse model of Rett syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Nuclear hormone receptor co-repressors: structure and function.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

The role of MeCP2 in the brain.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

L1 retrotransposition in neurons is modulated by MeCP2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

A temporal threshold for formaldehyde crosslinking and fixation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Isolation of neuronal chromatin from brain tissue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

InterRett and RettBASE: International Rett Syndrome Association databases for Rett syndrome.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Heterogeneity in residual function of MeCP2 carrying missense mutations in the methyl CpG binding domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Methylation-dependent silencing at the H19 imprinting control region by MeCP2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

A method for the generation of conditional gene repair mutations in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Functional consequences of Rett syndrome mutations on human MeCP2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Generation of purified neural precursors from embryonic stem cells by lineage selection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

MeCP2 Rett mutations affect large scale chromatin organization.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

RettBASE: The IRSA MECP2 variation database-a new mutation database in evolution

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3786392

Embryonic stem cells express neuronal properties in vitro

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/23770565

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NN.3434

1 reference

1 reference

1 reference

1 reference