Wikidata

(Q21988548)

English

Transcriptional regulator, SIN3A (yeast)

mammalian protein found in Mus musculus

  • Sin3a
  • transcriptional corepressor Sin3a
  • transcriptional regulator, SIN3 yeast homolog A
  • paired amphipathic helix protein Sin3a
  • histone deacetylase complex subunit Sin3a
In more languages

Statements

molecular function
protein binding
determination method
IPI
37 references
retrieved
8 April 2019
stated in
A molecular mechanism for circadian clock negative feedback
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs.
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors
GOA
curator
UniProt
UniProt protein ID
Q60520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Mnt transcriptional repressor is functionally regulated during cell cycle progression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Leukemia-related transcription factor TEL accelerates differentiation of Friend erythroleukemia cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
The Mad1-Sin3B interaction involves a novel helical fold
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
A positive regulatory role for the mSin3A-HDAC complex in pluripotency through Nanog and Sox2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
HDAC2 negatively regulates memory formation and synaptic plasticity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
retrieved
8 April 2019
stated in
HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IPI
cell component
biological process
negative regulation of transcription by RNA polymerase II
determination method
IBA
IEA
IGI
ISO
6 references
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
ISO
retrieved
8 April 2019
stated in
Role of EphA4 and EphrinB3 in local neuronal circuits that control walking
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IGI
retrieved
8 April 2019
stated in
Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IGI
retrieved
8 April 2019
stated in
RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60520
determination method
IBA

Identifiers

 
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