(Q21984970)

English

Arginase type II

mammalian protein found in Mus musculus

non-hepatic arginase
type II arginase
Arg2
arginase II
arginase-2, mitochondrial
kidney-type arginase

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Ureohydrolase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08691

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08691

Ureohydrolase, manganese-binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

hydrolase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

metal ion binding

determination method

2 references

arginase activity

determination method

4 references

31 October 2017

Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08691&geneProductId=UniProtKB:O08691

determination method

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08691&geneProductId=UniProtKB:O08691

determination method

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08691&geneProductId=UniProtKB:O08691

determination method

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08691&geneProductId=UniProtKB:O08691

determination method

arginase activity

determination method

5 references

14 February 2019

Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

manganese ion binding

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

nitric-oxide synthase binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

determination method

5 references

31 October 2017

Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08691&geneProductId=UniProtKB:O08691

determination method

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08691&geneProductId=UniProtKB:O08691

determination method

31 October 2017

Repression of arginase-2 expression in dendritic cells by microRNA-155 is critical for promoting T cell proliferation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08691&geneProductId=UniProtKB:O08691

determination method

31 October 2017

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08691&geneProductId=UniProtKB:O08691

determination method

31 October 2017

A mitochondrial protein compendium elucidates complex I disease biology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08691&geneProductId=UniProtKB:O08691

determination method

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

determination method

6 references

14 February 2019

Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

14 February 2019

Repression of arginase-2 expression in dendritic cells by microRNA-155 is critical for promoting T cell proliferation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

14 February 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

biological process

striated muscle contraction

determination method

1 reference

14 February 2019

Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

ureteric bud development

determination method

1 reference

14 February 2019

Spatial gene expression in the T-stage mouse metanephros

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

negative regulation of type 2 immune response

determination method

1 reference

14 February 2019

Increased mitochondrial arginine metabolism supports bioenergetics in asthma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

negative regulation of macrophage inflammatory protein 1 alpha production

determination method

1 reference

14 February 2019

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

negative regulation of chemokine (C-C motif) ligand 4 production

determination method

1 reference

14 February 2019

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

negative regulation of chemokine (C-C motif) ligand 5 production

determination method

1 reference

14 February 2019

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

negative regulation of defense response to bacterium

determination method

1 reference

14 February 2019

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

regulation of reactive oxygen species biosynthetic process

determination method

1 reference

14 February 2019

Increased mitochondrial arginine metabolism supports bioenergetics in asthma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process

determination method

1 reference

14 February 2019

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

negative regulation of CD4-positive, alpha-beta T cell proliferation

determination method

1 reference

14 February 2019

Repression of arginase-2 expression in dendritic cells by microRNA-155 is critical for promoting T cell proliferation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

adaptive immune response

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

immune system process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

innate immune response

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

arginine metabolic process

determination method

3 references

negative regulation of striated muscle contraction

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

negative regulation of nitric-oxide synthase activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08691

determination method

Ureohydrolase, manganese-binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08691

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000021550

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000021550

Sitelinks

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