(Q21985413)

http://www.ebi.ac.uk/interpro/protein/O09172

Glutamate--cysteine ligase regulatory subunit

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09172

NADP-dependent oxidoreductase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

enzyme regulator activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

glutamate-cysteine ligase catalytic subunit binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

glutamate-cysteine ligase activity

3 references

protein heterodimerization activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

glutamate-cysteine ligase complex

cell component

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

24 April 2018

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

24 April 2018

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

glutamate-cysteine ligase complex

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

cysteine metabolic process

biological process

1 reference

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

glutamate metabolic process

IMP

3 references

negative regulation of extrinsic apoptotic signaling pathway

1 reference

14 February 2019

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

glutathione biosynthetic process

IGI

6 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

24 April 2018

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

apoptotic mitochondrial changes

1 reference

14 February 2019

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

glutathione metabolic process

IGI

1 reference

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

response to oxidative stress

IMP

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

regulation of mitochondrial depolarization

1 reference

14 February 2019

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

cellular response to thyroxine stimulus

IGI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

response to human chorionic gonadotropin

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

cellular response to glucose stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

hepatic stellate cell activation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

cellular response to hepatocyte growth factor stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

cellular response to fibroblast growth factor stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

cellular response to follicle-stimulating hormone stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

cellular response to leukemia inhibitory factor

1 reference

14 February 2019

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

positive regulation of glutamate-cysteine ligase activity

IEP

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

24 April 2018

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

24 April 2018

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

24 April 2018

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09172&geneProductId=UniProtKB:O09172

glutathione biosynthetic process

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

positive regulation of glutamate-cysteine ligase activity

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09172

NADP-dependent oxidoreductase domain

has part(s)

1 reference

stated in

InterPro Release 71.0