(Q21985414)

http://www.ebi.ac.uk/interpro/protein/P97494

Glutamine synthetase/guanido kinase, catalytic domain

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97494

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

glutamate-cysteine ligase activity

10 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

magnesium ion binding

3 references

3 references

1 reference

14 February 2019

protein heterodimerization activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

glutamate-cysteine ligase activity

11 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

1 reference

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

glutamate-cysteine ligase complex

IDA

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

glutamate-cysteine ligase complex

IDA

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

1 reference

14 February 2019

Glutathione protects cells against arsenite-induced toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

glutathione metabolic process

1 reference

14 February 2019

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

cysteine metabolic process

3 references

negative regulation of extrinsic apoptotic signaling pathway

1 reference

14 February 2019

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

glutathione biosynthetic process

IGI

7 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

Glutathione synthesis is essential for mouse development but not for cell growth in culture

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

24 April 2018

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97494&geneProductId=UniProtKB:P97494

3 references

negative regulation of apoptotic process

3 references

response to arsenic-containing substance

1 reference

14 February 2019

Glutathione protects cells against arsenite-induced toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

response to oxidative stress

3 references

cell redox homeostasis

3 references

regulation of mitochondrial depolarization

1 reference

14 February 2019

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

negative regulation of protein ubiquitination

IGI

1 reference

14 February 2019

Glutathione protects cells against arsenite-induced toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

apoptotic mitochondrial changes

1 reference

14 February 2019

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

3 references

glutamate metabolic process

3 references

negative regulation of transcription, DNA-templated

3 references

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

14 February 2019

Glutathione protects cells against arsenite-induced toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

L-ascorbic acid metabolic process

1 reference

14 February 2019

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

cellular response to insulin stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

cellular response to hepatocyte growth factor stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

response to interleukin-1

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

cellular response to glucose stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

cellular response to mechanical stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

cellular response to thyroxine stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

cellular response to follicle-stimulating hormone stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

response to cadmium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

cellular response to fibroblast growth factor stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

response to human chorionic gonadotropin

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

glutathione biosynthetic process

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Glutathione synthesis is essential for mouse development but not for cell growth in culture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97494