(Q21985465)

http://www.ebi.ac.uk/interpro/protein/P20067

Helix-loop-helix DNA-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20067

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

22 March 2016

language of work or name

1 reference

22 March 2016

language of work or name

English

molecular function

protein self-association

1 reference

14 February 2019

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

protein dimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

5 references

14 February 2019

Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Acheron, an novel LA antigen family member, binds to CASK and forms a complex with Id transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Protein-protein interaction panel using mouse full-length cDNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

DNA-binding transcription factor activity

IPI

1 reference

24 April 2018

Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

DNA-binding transcription factor activity

transcription factor binding

3 references

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

24 April 2018

Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

24 April 2018

Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

8 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

24 April 2018

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

24 April 2018

Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

24 April 2018

Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

24 April 2018

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

negative regulation of gene expression

biological process

1 reference

14 February 2019

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

1 reference

24 April 2018

A role for Id2 in regulating photic entrainment of the mammalian circadian system

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

regulation of angiogenesis

IEP

1 reference

14 February 2019

Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

negative regulation of protein homodimerization activity

1 reference

14 February 2019

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

response to organic cyclic compound

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

cell-abiotic substrate adhesion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

regulation of transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

cellular response to dopamine

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

cellular response to transforming growth factor beta stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

collagen metabolic process

1 reference

14 February 2019

Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

cellular response to peptide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

BMP signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

negative regulation of DNA binding

1 reference

24 April 2018

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice

response to antibiotic

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

1 reference

14 February 2019

Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

endothelial cell morphogenesis

IGI

1 reference

14 February 2019

Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

cellular response to epidermal growth factor stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

lung vasculature development

1 reference

14 February 2019

Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

cellular response to nerve growth factor stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

negative regulation of osteoblast differentiation

1 reference

14 February 2019

Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

negative regulation of transcription, DNA-templated

IGI

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

A role for Id2 in regulating photic entrainment of the mammalian circadian system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

1 reference

14 February 2019

Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

neuron differentiation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20067&geneProductId=UniProtKB:P20067

regulation of MAPK cascade

1 reference

14 February 2019

Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

negative regulation of transcription by RNA polymerase II

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

A role for Id2 in regulating photic entrainment of the mammalian circadian system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

negative regulation of apoptotic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

transcription, DNA-templated

1 reference

14 February 2019

Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

negative regulation of DNA binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

negative regulation of neuron differentiation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

regulation of cell cycle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

negative regulation of cold-induced thermogenesis

1 reference

14 February 2019

Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20067

Myc-type, basic helix-loop-helix (bHLH) domain

has part(s)

1 reference

stated in

InterPro Release 71.0