(Q21985697)

English

Mitofusin 1

mammalian protein found in Mus musculus

mitofusin-1
Mfn1
transmembrane GTPase MFN1

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q811U4

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q811U4

Fzo/mitofusin HR2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

determination method

2 references

protein binding

determination method

5 references

14 February 2019

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

hydrolase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

GTPase activity

determination method

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

protein homodimerization activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

determination method

4 references

10 October 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q811U4&geneProductId=UniProtKB:Q811U4

determination method

10 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q811U4&geneProductId=UniProtKB:Q811U4

determination method

10 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q811U4&geneProductId=UniProtKB:Q811U4

determination method

10 October 2017

A mitochondrial protein compendium elucidates complex I disease biology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q811U4&geneProductId=UniProtKB:Q811U4

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

intrinsic component of mitochondrial outer membrane

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

integral component of membrane

determination method

4 references

10 October 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q811U4&geneProductId=UniProtKB:Q811U4

determination method

10 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q811U4&geneProductId=UniProtKB:Q811U4

determination method

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q811U4&geneProductId=UniProtKB:Q811U4

determination method

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q811U4&geneProductId=UniProtKB:Q811U4

determination method

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

mitochondrial outer membrane

determination method

3 references

mitochondrial inner membrane

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

integral component of membrane

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

integral component of mitochondrial outer membrane

determination method

3 references

outer mitochondrial membrane protein complex

determination method

3 references

biological process

mitochondrial fusion

determination method

4 references

10 October 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q811U4&geneProductId=UniProtKB:Q811U4

determination method

10 October 2017

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q811U4&geneProductId=UniProtKB:Q811U4

determination method

10 October 2017

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q811U4&geneProductId=UniProtKB:Q811U4

determination method

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q811U4&geneProductId=UniProtKB:Q811U4

determination method

multicellular organism development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

mitochondrion localization

determination method

mitochondrial fusion

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

positive regulation of mitochondrial fusion

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

GTP metabolic process

determination method

3 references

intracellular distribution of mitochondria

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

mitochondrion localization

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

positive regulation of dendritic spine morphogenesis

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

mitochondrion morphogenesis

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

negative regulation of mitochondrial fission

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q811U4

determination method

Dynamin-type guanine nucleotide-binding (G) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q811U4

Fzo/mitofusin HR2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q811U4

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000088801

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000088801

ENSMUSP00000113251

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000113251

ENSMUSP00000116380

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000116380

ENSMUSP00000117411

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000117411

ENSMUSP00000120960

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000120960

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

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