(Q21985962)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5XJY4

Peptidase S54, rhomboid domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

31 January 2018

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

1 reference

8 April 2019

serine-type peptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

1 reference

8 April 2019

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

1 reference

8 April 2019

serine-type endopeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5XJY4&geneProductId=UniProtKB:Q5XJY4

1 reference

16 September 2017

protein binding

IPI

1 reference

8 April 2019

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

IPI

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

1 reference

8 April 2019

mitochondrion

3 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5XJY4&geneProductId=UniProtKB:Q5XJY4

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5XJY4&geneProductId=UniProtKB:Q5XJY4

16 September 2017

16 September 2017

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5XJY4&geneProductId=UniProtKB:Q5XJY4

IDA

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5XJY4&geneProductId=UniProtKB:Q5XJY4

1 reference

16 September 2017

mitochondrion

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

IBA

8 April 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

mitochondrial inner membrane

HDA

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

negative regulation of release of cytochrome c from mitochondria

IBA

biological process

1 reference

8 April 2019

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

regulation of autophagy of mitochondrion

1 reference

8 April 2019

Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

proteolysis

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

8 April 2019

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

8 April 2019

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

8 April 2019

negative regulation of intrinsic apoptotic signaling pathway

1 reference

8 April 2019

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

regulation of mitochondrion organization

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5XJY4&geneProductId=UniProtKB:Q5XJY4

regulation of proteolysis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

regulation of protein targeting to mitochondrion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

regulation of reactive oxygen species metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5XJY4

Peptidase S54, rhomboid domain

has part(s)

1 reference

InterPro Release 71.0