(Q21986053)

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, LIM-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

3 references

transcription coactivator activity

6 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

24 April 2018

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

16 July 2018

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

3 references

14 February 2019

Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

7 references

14 February 2019

Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

promoter-specific chromatin binding

IPI

1 reference

14 February 2019

Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

sequence-specific DNA binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

transcription coactivator activity

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

transcription coactivator activity

1 reference

14 February 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

3 references

14 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

Conversion of biliary system to pancreatic tissue in Hes1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

Role of Islet1 in the patterning of murine dentition

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

15 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Conversion of biliary system to pancreatic tissue in Hes1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Role of Islet1 in the patterning of murine dentition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

negative regulation of neuron apoptotic process

IBA

biological process

1 reference

14 February 2019

A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

peripheral nervous system neuron development

1 reference

14 February 2019

Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of interleukin-1 alpha production

1 reference

14 February 2019

Islet-1 gene delivery improves myocardial performance after experimental infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

pituitary gland development

1 reference

14 February 2019

Formation of Rathke's pouch requires dual induction from the diencephalon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

negative regulation of neuron differentiation

1 reference

14 February 2019

A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of interleukin-12 production

1 reference

14 February 2019

Islet-1 gene delivery improves myocardial performance after experimental infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

spinal cord motor neuron cell fate specification

1 reference

14 February 2019

Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

trigeminal nerve development

1 reference

14 February 2019

A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

neuron fate specification

1 reference

1 January 2018

A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 reference

14 February 2019

Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

outflow tract morphogenesis

1 reference

14 February 2019

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of interferon-gamma production

1 reference

14 February 2019

Islet-1 gene delivery improves myocardial performance after experimental infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of granulocyte colony-stimulating factor production

1 reference

14 February 2019

Islet-1 gene delivery improves myocardial performance after experimental infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of angiogenesis

1 reference

14 February 2019

Islet-1 gene delivery improves myocardial performance after experimental infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of histone acetylation

1 reference

14 February 2019

Islet-1 may function as an assistant factor for histone acetylation and regulation of cardiac development-related transcription factor Mef2c expression

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

outflow tract septum morphogenesis

1 reference

14 February 2019

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

endocardial cushion morphogenesis

1 reference

14 February 2019

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

ventricular cardiac muscle tissue morphogenesis

1 reference

14 February 2019

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

atrial septum morphogenesis

1 reference

14 February 2019

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

cardiac cell fate determination

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

1 reference

14 February 2019

Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

regulation of secondary heart field cardioblast proliferation

1 reference

14 February 2019

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

cardiac muscle cell myoblast differentiation

1 reference

14 February 2019

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

cellular response to glucocorticoid stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

visceral motor neuron differentiation

1 reference

14 February 2019

A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

mesenchymal cell differentiation

1 reference

14 February 2019

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of granulocyte macrophage colony-stimulating factor production

1 reference

14 February 2019

Islet-1 gene delivery improves myocardial performance after experimental infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

neural crest cell migration

1 reference

14 February 2019

Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation

neuron differentiation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of cell population proliferation

1 reference

14 February 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of interleukin-1 beta production

1 reference

14 February 2019

Islet-1 gene delivery improves myocardial performance after experimental infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of interleukin-6 production

1 reference

14 February 2019

Islet-1 gene delivery improves myocardial performance after experimental infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of tumor necrosis factor production

1 reference

14 February 2019

Islet-1 gene delivery improves myocardial performance after experimental infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

regulation of gene expression

1 reference

14 February 2019

Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

1 reference

14 February 2019

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of macrophage colony-stimulating factor production

1 reference

14 February 2019

Islet-1 gene delivery improves myocardial performance after experimental infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of vascular endothelial growth factor production

1 reference

14 February 2019

Islet-1 gene delivery improves myocardial performance after experimental infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity

neuron fate commitment

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of DNA binding

1 reference

14 February 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

peripheral nervous system neuron axonogenesis

1 reference

14 February 2019

A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

spinal cord motor neuron differentiation

1 reference

14 February 2019

Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

1 reference

14 February 2019

A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

negative regulation of inflammatory response

ISS

1 reference

14 February 2019

Islet-1 gene delivery improves myocardial performance after experimental infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

cardiac right ventricle morphogenesis

1 reference

14 February 2019

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

negative regulation of canonical Wnt signaling pathway

1 reference

14 February 2019

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

sensory system development

1 reference

14 February 2019

A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

pharyngeal system development

1 reference

14 February 2019

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

retinal ganglion cell axon guidance

1 reference

14 February 2019

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

transcription by RNA polymerase II

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

positive regulation of transcription by RNA polymerase II

8 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 January 2018

CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

positive regulation of cell differentiation

1 reference

14 February 2019

Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

14 February 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

regulation of transcription, DNA-templated

3 references

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

positive regulation of transcription by RNA polymerase II

IBA

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372

1 reference

Zinc finger, LIM-type

1 reference

stated in

Homeobox, conserved site

1 reference

stated in