(Q21986073)

Mir domain superfamily

1 reference

inositol 1,4,5-trisphosphate receptors

1 reference

Inositol 1,4,5-trisphosphate/ryanodine receptor domain, protein family

1 reference

Ion transport domain, protein family

1 reference

MIR motif domain, protein family

1 reference

RyR/IP3R Homology associated domain, protein family

1 reference

RIH domain, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

calcium channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

2 references

6 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70227&geneProductId=UniProtKB:P70227

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70227&geneProductId=UniProtKB:P70227

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70227&geneProductId=UniProtKB:P70227

24 April 2018

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70227&geneProductId=UniProtKB:P70227

24 April 2018

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70227&geneProductId=UniProtKB:P70227

24 April 2018

The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70227&geneProductId=UniProtKB:P70227

calcium-release channel activity

1 reference

14 February 2019

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

inositol 1,4,5 trisphosphate binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

6 references

14 February 2019

The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

PML regulates apoptosis at endoplasmic reticulum by modulating calcium release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

Lrmp/Jaw1 is expressed in sweet, bitter, and umami receptor-expressing cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

A dual role for Integrin α6β4 in modulating Hereditary Neuropathy with liability to Pressure Palsies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

phosphatidylinositol binding

IPI

1 reference

24 April 2018

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70227&geneProductId=UniProtKB:P70227

inositol hexakisphosphate binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

inositol 1,3,4,5 tetrakisphosphate binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

inositol 1,4,5 trisphosphate binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

integral component of membrane

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

endoplasmic reticulum membrane

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70227&geneProductId=UniProtKB:P70227

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70227&geneProductId=UniProtKB:P70227

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70227&geneProductId=UniProtKB:P70227

24 April 2018

PML regulates apoptosis at endoplasmic reticulum by modulating calcium release

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70227&geneProductId=UniProtKB:P70227

1 reference

14 February 2019

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

1 reference

14 February 2019

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

1 reference

14 February 2019

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

nuclear outer membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

endoplasmic reticulum

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

perinuclear region of cytoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

endoplasmic reticulum membrane

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

PML regulates apoptosis at endoplasmic reticulum by modulating calcium release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

sarcoplasmic reticulum

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

integral component of endoplasmic reticulum membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

cytoplasmic vesicle membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

secretory granule membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

sensory perception of umami taste

biological process

1 reference

14 February 2019

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

calcium ion transport into cytosol

1 reference

14 February 2019

PML regulates apoptosis at endoplasmic reticulum by modulating calcium release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

2 references

1 reference

14 February 2019

Impaired fear memory, altered object memory and modified hippocampal synaptic plasticity in split-brain mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

sensory perception of bitter taste

1 reference

14 February 2019

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

calcium ion transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

2 references

transmembrane transport

1 reference

14 February 2019

sensory perception of sweet taste

1 reference

14 February 2019

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

calcium ion transport

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

14 February 2019

The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

Impaired fear memory, altered object memory and modified hippocampal synaptic plasticity in split-brain mice

long-term potentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

release of sequestered calcium ion into cytosol

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70227&geneProductId=UniProtKB:P70227

inositol phosphate-mediated signaling

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

G protein-coupled receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

positive regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

protein homooligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

protein heterooligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

cellular response to cAMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

release of sequestered calcium ion into cytosol

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70227

1 reference

Inositol 1,4,5-trisphosphate/ryanodine receptor domain

1 reference

MIR motif

1 reference

Ion transport domain

1 reference

RyR/IP3R Homology associated domain

1 reference