(Q21986514)

http://www.ebi.ac.uk/interpro/protein/O54992

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

protein kinase activity

3 references

14 February 2019

14 February 2019

The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

calcium-dependent protein serine/threonine kinase activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

mitogen-activated protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

protein serine/threonine kinase activity

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

PRAK is essential for ras-induced senescence and tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

3 references

14 February 2019

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

calmodulin-dependent protein kinase activity

IPI

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

2 references

signal transducer activity

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

mitogen-activated protein kinase binding

3 references

14 February 2019

Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

1 reference

14 February 2019

The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

27 March 2018

Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

27 March 2018

Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

27 March 2018

The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

27 March 2018

Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

27 March 2018

Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

27 March 2018

The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

protein-containing complex

ISO

1 reference

14 February 2019

The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

positive regulation of telomere capping

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

positive regulation of telomere maintenance via telomerase

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

positive regulation of dendritic spine development

ISO

2 references

14 February 2019

The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

IGI

protein phosphorylation

1 reference

14 February 2019

negative regulation of TOR signaling

1 reference

14 February 2019

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

peptidyl-serine phosphorylation

IDA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

positive regulation of telomerase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

protein autophosphorylation

ISO

3 references

regulation of translation

2 references

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

cell surface receptor signaling pathway

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54992&geneProductId=UniProtKB:O54992

Ras protein signal transduction

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

PRAK is essential for ras-induced senescence and tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

intracellular signal transduction

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54992

serine/threonine-protein kinase, active site

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54992

protein kinase domain

1 reference

stated in

InterPro Release 71.0